Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
First Claim
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1. A method for preparing a medical article comprising forming a layer of a polymeric material containing an antiinfective agent selected from the group consisting of a biguanide and silver sulfadiazine bulk distributed therein onto a surface of a preformed hydrophilic polymeric article.
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Abstract
A method of preparing an infection-resistant medical device comprising one or more matrix-forming polymers selected from the group consisting of biomedical polyurethane, biomedical silicones and biodegradable polymers, and antimicrobial agents, especially a synergistic combination of a silver salt and chlorhexidine (or its salts); also disclosed are medical devices having the synergistic composition therein or compositions thereon.
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2 Claims
- 1. A method for preparing a medical article comprising forming a layer of a polymeric material containing an antiinfective agent selected from the group consisting of a biguanide and silver sulfadiazine bulk distributed therein onto a surface of a preformed hydrophilic polymeric article.
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