Medicaments comprising glicentin as active ingredient

• US 5,616,558 A
• Filed: 06/30/1993
• Issued: 04/01/1997
• Est. Priority Date: 07/13/1992
• Status: Expired due to Fees

• Current Assignee: Nisshin Seifun Group Incorporated
• Original Assignee: Nisshin Flour Milling Incorporated (Nisshin Seifun Group Incorporated)
• Inventors: Sasaki, Kazuyuki, Natori, Yohei, Ohneda, Akira, Nagasaki, Tomohisa
• Primary Examiner(s): Schain, Howard E.
• Assistant Examiner(s): TOUZEAU, LYNN
• Application Number:
  US08/083,501
• Time in Patent Office: 1,371 Days
• Field of Search: 530/324, 514/12
• US Class Current: 514/5.9
• CPC Class Codes: A61K 38/26 Glucagons
• CPC Class Codes: C07K 14/605 Glucagons

Abstract

Agents for stimulating insulin secretion and for treating diabetes which comprise glicentin as an active ingredient.

Claims

1. A method for stimulating insulin secretion comprising:

administering an effective amount of glicentin and a pharmaceutically acceptable carrier or excipient to an individual in need thereof.

2. The method of claim 1, wherein glicentin is human glicentin.

3. The method of claim 2, wherein human glicentin has the following amino acid sequence:

space="preserve" listing-type="tabular">__________________________________________________________________________Arg--Ser--Leu--Gln--Asp--Thr--Glu--Glu--Lys--Ser--Arg--Ser--Phe--Ser--Ala-Ser--Gln--Ala--Asp--Pro--Leu--Ser--Asp--Pro--Asp--Gln--Met--Asn--Glu--Asp-Lys--Arg--His--Ser--Gln--Gly--Thr--Phe--Thr--Ser--Asp--Tyr--Ser--Lys--Tyr-Leu--Asp--Ser--Arg--Arg--Ala--Gln--Asp--Phe--Val--Gln--Trp--Leu--Met--Asn-Thr--Lys--Arg--Asn--Arg--Asn--Asn--Ile--Ala. __________________________________________________________________________

4. The method of claim 2, wherein human glicentin has the following amino acid sequence:

space="preserve" listing-type="tabular">__________________________________________________________________________Met--Arg--Ser--Leu--Gln--Arg--Thr--Gln--Glu--Lys--Ser--Arg--Ser--Phe--Ser-Ala--Ser--Gln--Ala--Asp--Pro--Leu--Ser--Asp--Pro--Asp--Gln--Met--Asn--Glu-Asp--Lys--Arg--His--Ser--Gln--Gly--Thr--Phe--Thr--Ser--Asp--Tyr--Ser--Lys-Tyr--Leu--Asp--Ser--Arg--Arg--Ala--Gln--Asp--Phe--Val--Gln--Trp--Leu--Met-Asn--Thr--Lys--Arg--Asn--Arg--Asn--Asn--Ile--Ala __________________________________________________________________________