Taste masking liquids
First Claim
1. A pharmaceutical composition comprising (i) a liquid excipient base consisting essentially of water and per 100 milliliters of said base about 5 to about 20 grams of a (a) polyethylene glycol having a molecular weight of about 950 to about 2200, and (b) a cellulosic compound selected from the group consisting of methyl cellulose, hydroxyethycellulose, hydroxypropylcellulose, hydroxyethyl methylcellulose, hydroxyproply methylcellulose, carboxymethyl cellulose, mixtures and salts thereof, the weight ratio of said polyethylene glycol to said cellulosic compound being between about 100:
- 1 and about 20;
1, and the spindle viscosity of the liquid excipient base being between about 150 and about 1000 centipoises at 50 RPM and 150-1200 centipoises at 10 RPM, and (ii) at least one pharmaceutically active compound selected from the group consisting of antihistamines, decongestants, antitussives, expectorants, non-steroidal anti-inflammatory drugs (NSAIDs) and analgesic drugs, said pharmaceutically active compound being dissolved in the liquid excipient base.
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Accused Products
Abstract
There is provided a pharmaceutically acceptable taste masking liquid excipient base for administration of relatively large amounts of unpleasant tasting medicines, said excipient base having higher than normal viscosities due to a combination of polyethylene glycol and cellulosic material.
59 Citations
44 Claims
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1. A pharmaceutical composition comprising (i) a liquid excipient base consisting essentially of water and per 100 milliliters of said base about 5 to about 20 grams of a (a) polyethylene glycol having a molecular weight of about 950 to about 2200, and (b) a cellulosic compound selected from the group consisting of methyl cellulose, hydroxyethycellulose, hydroxypropylcellulose, hydroxyethyl methylcellulose, hydroxyproply methylcellulose, carboxymethyl cellulose, mixtures and salts thereof, the weight ratio of said polyethylene glycol to said cellulosic compound being between about 100:
- 1 and about 20;
1, and the spindle viscosity of the liquid excipient base being between about 150 and about 1000 centipoises at 50 RPM and 150-1200 centipoises at 10 RPM, and (ii) at least one pharmaceutically active compound selected from the group consisting of antihistamines, decongestants, antitussives, expectorants, non-steroidal anti-inflammatory drugs (NSAIDs) and analgesic drugs, said pharmaceutically active compound being dissolved in the liquid excipient base. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- 1 and about 20;
- 20. A method for taste masking at least one unpleasant tasting pharmaceutically active compound comprising dissolving such unpleasant tasting pharmaceutically active compound into a liquid excipient base consisting essentially of water, polyethylene glycol having a molecular weight of about 950 to about 2200, and a cellulosic compound selected from the group consisting of methyl cellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxyethyl methylcellulose, hydroxypropyl methylcellulose, carboxymethyl cellulose, mixtures and salts thereof, the spindle viscosity of the liquid excipient base being between about 150 and about 1000 centipoises at 50 RPM and 150-1200 centipoises at 10 RPM.
Specification