Ultrasonic method and apparatus for cosmetic and dermatological applications
First Claim
1. The method of facilitating the penetration of a therapeutic agent through a person'"'"'s skin comprising, applying relatively low frequency ultrasonic pressure waves in a range of about 15000 to about 25000 Hz to the skin of sufficiently high intensity to cause cavitation in the skin thereby opening up passageways through the stratum corneum by disordering the lipid bilayers and increasing the permeability of the skin to allow the penetration of a therapeutic agent for a limited time period, terminating the application of low frequency ultrasonic pressure waves to the skin, then promptly applying a therapeutic agent to the skin before the natural function of the person'"'"'s body decreases the permeability of the skin and restores the normal environmental protection of the body;
- and subsequently applying gentle high frequency noncavitating ultrasonic vibrations to the keratin fibers and the surrounding lipid bilayers of the stratum corneum to augment the body'"'"'s natural function to reestablish the order of the lipid bilayers and to effectively seal the body against further penetration of invading molecules.
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Accused Products
Abstract
Low frequency ultrasonic pressure waves of high intensity are applied to the skin to cause cavitation. A therapeutic agent may be applied to the skin in a predetermined amount prior to the application of the pressure waves. The therapeutic agent may also be applied to the skin subsequent to the application of the pressure waves. Ultrasonic pressure waves of high frequency which do not cause cavitation may be applied to the skin after delivery of a therapeutic agent. The depth of penetration of the agent may be controlled by varying the burst width of electrical signals applied to a piezoelectric transducer. A housing surrounds the transducer and a sleeve may be provided to define with the housing a predetermined controlled volume chamber for holding a measured amount of agent. An ultrasonic power supply includes means for generating both low and high ultrasonic frequency electric signals, and a switch alternatively connects the high and low frequency signals to the transducer.
446 Citations
11 Claims
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1. The method of facilitating the penetration of a therapeutic agent through a person'"'"'s skin comprising, applying relatively low frequency ultrasonic pressure waves in a range of about 15000 to about 25000 Hz to the skin of sufficiently high intensity to cause cavitation in the skin thereby opening up passageways through the stratum corneum by disordering the lipid bilayers and increasing the permeability of the skin to allow the penetration of a therapeutic agent for a limited time period, terminating the application of low frequency ultrasonic pressure waves to the skin, then promptly applying a therapeutic agent to the skin before the natural function of the person'"'"'s body decreases the permeability of the skin and restores the normal environmental protection of the body;
- and subsequently applying gentle high frequency noncavitating ultrasonic vibrations to the keratin fibers and the surrounding lipid bilayers of the stratum corneum to augment the body'"'"'s natural function to reestablish the order of the lipid bilayers and to effectively seal the body against further penetration of invading molecules.
- View Dependent Claims (2, 3, 4, 5)
- 6. The method of facilitating the penetration of a therapeutic agent through a person'"'"'s skin comprising, applying a therapeutic agent to the skin, then applying through the therapeutic agent relatively low frequency ultrasonic pressure waves to the skin of sufficiently high intensity to force said therapeutic agent into the skin and concurrently cause cavitation in the skin thereby opening up passageways through the stratum corneum by disordering the lipid bilayers and increasing the permeability of the skin to allow the penetration of the therapeutic agent, subsequently terminating the application of low frequency ultrasonic pressure waves to the skin, and applying relatively high frequency noncavitating ultrasonic vibrations into the keratin fibers and the surrounding lipid bilayers of the stratum corneum to augment the body'"'"'s natural function to reestablish the order of the lipid bilayers and to effectively seal the body against further penetration of invading molecules.
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11. Apparatus for facilitating the penetration of a therapeutic agent through a person'"'"'s skin and driving said agent into the skin comprising, a housing, said housing supporting a piezoelectric transducer including at least one active element for contracting and expanding volumetrically when energized in response to a changing electrical field and generating vibrations of ultrasonic energy, an ultrasonic power supply to generate ultrasonic frequency electric signals, means coupling said power supply to said piezoelectric transducer, and a sleeve coupled to the housing having an open end and defining a measuring chamber of a predetermined control volume for supporting a predetermined controlled amount of therapeutic agent therein in contact with the skin to couple the ultrasonic vibrations through said therapeutic agent to the skin whereby an accurately controlled amount of said therapeutic agent is driven into the skin wherein said open end of said sleeve has a flexible marginal edge for forming a seal for the chamber with the skin and wherein said ultrasonic vibrations pass through the open end during operation.
Specification