Non-reactive lubicious coating process

• US 5,620,738 A
• Filed: 06/07/1995
• Issued: 04/15/1997
• Est. Priority Date: 06/07/1995
• Status: Expired due to Term

• Current Assignee: Union Carbide Chemicals & Plastics Technology Corporation (Dow, Inc.)
• Original Assignee: Union Carbide Chemicals & Plastics Technology Corporation (Dow, Inc.)
• Inventors: Fan, You L., Marino, Isabel M., Marlin, Lawrence, Bouldin, Lisa M.
• Primary Examiner(s): DUDASH, DIANA L
• Application Number:
  US08/486,413
• Time in Patent Office: 678 Days
• Field of Search: 427/2.24, 427/2.3, 427/2.28, 427/2.1, 427/407.1, 427/385.5, 427/388.1, 427/389.7, 427/393.5
• US Class Current: 427/2.3
• CPC Class Codes: A61L 2400/10 Materials for lubricating medical devices
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: C08L 27/06 Homopolymers or copolymers of vinyl chloride
• CPC Class Codes: C08L 31/04 Homopolymers or copolymers of vinyl acetate
• CPC Class Codes: C08L 33/02 Homopolymers or copolymers of acids; Metal or ammonium salts thereof
• CPC Class Codes: C10M 177/00 Special methods of preparation of lubricating compositions; Chemical modification by after-treatment of components or of the whole of a lubricating composition, not covered by other classes

Abstract

Lubricious coatings comprising a binder polymer which is a copolymer of vinyl chloride, vinyl acetate and a carboxylic acid moiety and a hydrophilic polymer are disclosed. The coatings can be applied to a variety of substrates such as, for example, catheters, stents, dilatation balloons, guide wires, endotracheal tubes, instruments, implants and other biomedical devices and can provide exceptional lubricity and abrasion resistance. Processes for applying the lubricious coatings in either one or two coating steps are also disclosed.

Claims

1. A process for applying a lubricious coating to a surface of a substrate comprising contacting the surface with:

(i) a hydrophilic polymer which is substantially more lubricious when wetted with an aqueous liquid than when dry; and

(ii) a binder polymer which is a copolymer of vinyl chloride, vinyl acetate and a carboxylic acid

wherein there is less than about 5% of covalent bonding between the binder polymer and the hydrophilic polymer based on the total number of bonding sites between the binder polymer and the hydrophilic polymer.

2. The process of claim 1 wherein said substrate is selected from the group consisting of polyurethane, polyvinyl chloride, polyacrylate, polycarbonate, polystryrene, polyester resins, polybutadiene-styrene copolymers, nylon, polyethylene, polypropylene, polybutylene, silicon, polyvinyl acetate, polymethacrylate, polysulfone, polyisoprene, and copolymers thereof, glass, metal, ceramic and mixtures thereof.

3. The process of claim 1 wherein the binder polymer has a number average molecular weight of from about 5,000 to 1,000,000 grams per gram mole.

4. The process of claim 1 wherein the hydrophilic polymer is selected from the group consisting of polyvinyl compounds, polysaccharides, polyurethanes, polyacrylates, polyacrylamides, polyalkyleneoxides and copolymers, complexes and mixtures thereof.

5. The process of claim 4 wherein the hydrophilic polymer is selected from the group consisting of polyN-vinylpyrrolidone, polyN-vinylpyrrolidone copolymers, carboxymethylcellulose, polyacrylic acid, cationically-modified hydroxyethylcellulose, polyethylene oxides, polyethylene oxide copolymers, complexes and mixtures thereof.

6. The process of claim 4 wherein the hydrophilic polymer is cationic, anionic or amphoteric.

7. The process of claim 6 which further comprises an additive which is ionically bonded or hydrogen bonded to the hydrophilic polymer.

8. The process of claim 7 wherein the additive is selected from the group consisting of therapeutic agents, anti-thrombogenic agents, antimicrobial agents, antibiotics and mixtures thereof.

9. The process of claim 1 wherein the surface is contacted with a first liquid medium comprising the binder polymer and subsequently contacted with a second liquid medium comprising the hydrophilic polymer.

10. The process of claim 9 further comprising drying the surface prior to contacting with the second liquid medium.

11. The process of claim 1 wherein the surface is contacted with a common liquid medium comprising the binder polymer and the hydrophilic polymer.

12. The process of claim 11 further comprising drying the surface after contacting with the common liquid medium.

13. The process of claim 1 wherein there is less than about 1% of covalent bonds between the binder polymer and the hydrophilic polymer based on the total number of bonding sites between the binder polymer and the hydrophilic polymer.

14. The process of claim 1 wherein the binder polymer comprises less than about 1% of moieties selected from the group consisting of isocyanate, aldehyde and epoxy moieties.

15. A process for applying a lubricious coating to a surface of a substrate comprising contacting the surface with:

(i) a hydrophilic polymer which is substantially more lubricious when wetted with an aqueous liquid than when dry; and

(ii) a binder polymer which is a copolymer of vinyl chloride, vinyl acetate and at least one of maleic acid or acrylic acid

wherein there is less than about 5% of covalent bonding between the binder polymer and the hydrophilic polymer based on the total number of bonding sites between the binder polymer and the hydrophilic polymer.