Wound disinfection and repair
First Claim
1. A method for the treatment or prevention of microbial infections in a mammal having a peritoneal cavity catheter comprising infusing into the cavity or around the catheter an effective amount of a composition that is compatible with the peritoneal cavity comprising a pharmacologically acceptable carrier that is a peritoneal dialysis solution and chlorine dioxide in an amount ranging from greater than 125 ppm to about 1000 ppm, where the molar ratio of chlorine dioxide to any residual chlorite in the composition is at least 5:
- 1 and the pH of the composition is about 5 to 7.5.
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Abstract
Methods for preventing and treating microbial wound infections, especially of peritoneal cavity wounds including those having indwelling catheters, and enhancing wound repair while minimizing adhesions and scar formation involve the infusion or irrigation of the wound with a solution containing a pharmacologically acceptable carrier and chlorine dioxide in an amount ranging from about 5 ppm to 1000 ppm, and having a chlorine dioxide to chlorite ratio of at least 5:1. Typical solutions contain chlorine dioxide in isotonic saline and exhibit a pH of from about 5 to about 7.5. Sodium chlorite is employed in preferred embodiments.
107 Citations
25 Claims
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1. A method for the treatment or prevention of microbial infections in a mammal having a peritoneal cavity catheter comprising infusing into the cavity or around the catheter an effective amount of a composition that is compatible with the peritoneal cavity comprising a pharmacologically acceptable carrier that is a peritoneal dialysis solution and chlorine dioxide in an amount ranging from greater than 125 ppm to about 1000 ppm, where the molar ratio of chlorine dioxide to any residual chlorite in the composition is at least 5:
- 1 and the pH of the composition is about 5 to 7.5.
- View Dependent Claims (2, 3, 4, 5)
- 6. A method for irrigating a peritoneal cavity wound to disinfect the wound and promote healing, comprising infusing the wound with a composition that is compatible with the peritoneal cavity comprising greater than 125 ppm to 1000 ppm chlorine dioxide in a pharmaceutically acceptable carrier having a pH of about 5 to about 7.5, provided that the molar ratio of chlorine dioxide to chlorite in the composition is at least 5:
- 19. A method for treating or preventing a microbial infection in the peritoneal cavity of a mammal comprising infusing into the cavity an effective amount of a composition comprising chlorine dioxide in a pharmacologically acceptable carrier, wherein the molar ratio of chlorine dioxide to chlorite in the composition is at least 5.1, wherein the composition contains from greater than 125 ppm to about 1000 ppm chlorine dioxide and is compatible with the peritoneal cavity.
Specification