Method of detecting an obstruction in a fluid flow line of a medical laboratory instrument

• US 5,622,869 A
• Filed: 07/10/1995
• Issued: 04/22/1997
• Est. Priority Date: 02/16/1994
• Status: Expired due to Fees

• Current Assignee: Akzo Nobel N.V. (Nouryon BV)
• Original Assignee: Akzo Nobel N.V. (Nouryon BV)
• Inventors: Moreno, Mario, Lewis, Gregory D., Keiter, Dean L.
• Primary Examiner(s): ALEXANDER, LYLE
• Application Number:
  US08/500,073
• Time in Patent Office: 652 Days
• Field of Search: 422/81, 422/82.13, 422/44, 422/103, 422/104, 422/73, 436/48, 436/50, 436/52, 436/55, 436/148, 73/37, 73/49.5, 73/49.6, 73/49.8
• US Class Current: 436/148
• CPC Class Codes: G01L 9/0001 Transmitting or indicating the displacement of elastically deformable gauges by electric, electro-mechanical, magnetic or electro-magnetic means G01L9/0026, G01L9/0033, G01L9/0082, G01L9/0089, G01L9/0091 take precedence
• CPC Class Codes: G01N 2035/1018 Detecting inhomogeneities, e.g. foam, bubbles, clots
• CPC Class Codes: G01N 35/1016 Control of the volume dispensed or introduced
• CPC Class Codes: Y10T 436/114165 with step of insertion or removal from test line
• CPC Class Codes: Y10T 436/117497 with a continuously flowing sample or carrier stream
• CPC Class Codes: Y10T 436/12 Condition responsive control

Abstract

An apparatus for detecting obstructions of a flow line. A detector housing is provided having a cavity therein. The detector housing has first and second openings into the cavity. The flow line is attached to the detector housing establishing a flow path through the first opening, the cavity, and the second opening, respectively. A pressure detector detects changes in pressure within the cavity, indicating the presence of an obstruction.

Claims

1. A method for detecting obstructions in a fluid flow path of an automated sample handling system, comprising:

moving a sample tube to a sample removing station where an automated probe is positioned, said automated probe being in fluid communication with a pump, a fluid flow path being defined between said pump and said probe;

with said probe positioned above said sample tube, lowering said probe a predetermined distance into said sample tube;

aspirating into said probe a predetermined amount of sample from said sample tube;

removing said probe from said sample tube; and

dispensing said sample from said probe into a test well;

wherein at commencement of said aspiration step, said pump causes an initial vacuum for drawing sample from said sample tube, after said initial vacuum but within said aspiration step, a change in pressure is detected within said fluid flow path which indicates the presence or absence of obstructions preventing said predetermined amount of fluid from being drawn from said sample tube.

2. A method for detecting obstructions according to claim 1, wherein said aspiration source is a pump.

3. A method for detecting obstructions according to claim 1, wherein said change in pressure is monitored at an end of said aspiration step.

4. A method for detecting obstructions according to claim 3, wherein said change in pressure is integrated to derive actual pressure, said actual pressure being used to determine the presence or absence of an obstruction in said flow path.

5. A method for detecting obstructions according to claim 3, wherein in said aspiration step where said obstruction is not present, an abrupt pressure increase is detected at the end of said aspiration step, whereas when said obstruction is present, said abrupt pressure increase is reduced, delayed and/or absent thus allowing said detection of said obstruction.

6. A method for detecting obstructions according to claim 5, wherein during said aspiration step, fluid is drawn into said fluid flow path due to movement of a plunger within said pump, and wherein when movement of said pump plunger stops at the end of said aspiration step, said fluid drawn into said fluid flow path impinges on said pump plunger and causes said abrupt pressure increase.

7. A method for detecting obstructions according to claim 1, wherein said pressure is monitored by means of a pressure detector which detects expansion and contraction of a surface adjacent said fluid flow path.

8. A method for detecting obstructions according to claim 7, wherein said pressure detector measures microstrain corresponding to a time rate of change of pressure within said fluid flow path.

9. A method for detecting obstructions according to claim 8, wherein a housing is disposed within and in fluid communication with said fluid flow path, and wherein said pressure detector is disposed on said housing for measuring changes in pressure within said housing.

10. A method for detecting obstructions according to claim 9, wherein said housing has a greater circumferential surface area than a circumferential surface area of a fluid flow line defining said fluid flow path.

11. A method for detecting obstructions according to claim 8, wherein said pressure detector is a piezoelectric device.

12. A method for detecting obstructions according to claim 11, wherein said piezoelectric device is piezoelectric tape.