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Thioether conjugates

  • US 5,622,929 A
  • Filed: 01/23/1992
  • Issued: 04/22/1997
  • Est. Priority Date: 01/23/1992
  • Status: Expired due to Fees
First Claim
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1. A compound of Formula (I):

  • ##STR32## in which D is an anthracycline antibiotic;

    n is an integer from 1 to 10;

    p is an integer from 1 to 6;

    Y is O or NH2+ Cl- ;

    a is 0 or 1;

    q is about 1 to about 10;

    X is a ligand that specifically binds with a target cell population; and

    A is a succinimido moiety;

    wherein the anthracycline antibiotic is bound through the 13-keto position of the anthracycline.

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