Controlled release of drugs delivered by sublingual or buccal administration
First Claim
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1. A composition providing a relatively slow release of water-soluble drugs by sublingual route and consisting essentially of:
- about 2 to about 10 milligrams of a water-soluble drug which is a member of the group consisting of apomorphine hydrochloride, albuterol sulfate, timolol maleate, verapamil hydrochloride, and naloxone hydrochloride, and;
an osmotic agent;
a swellable hydrophilic carrier;
and a water dispersible polymer;
the composition having a T90 value in the range of more than about 25 to about 300.
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Abstract
A composition providing a relatively slow release of water-soluble drugs, such as apomorphine, for delivery via the sublingual or buccal routes.
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20 Claims
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1. A composition providing a relatively slow release of water-soluble drugs by sublingual route and consisting essentially of:
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about 2 to about 10 milligrams of a water-soluble drug which is a member of the group consisting of apomorphine hydrochloride, albuterol sulfate, timolol maleate, verapamil hydrochloride, and naloxone hydrochloride, and; an osmotic agent; a swellable hydrophilic carrier; and a water dispersible polymer; the composition having a T90 value in the range of more than about 25 to about 300. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification