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In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom

  • US 5,624,803 A
  • Filed: 10/13/1994
  • Issued: 04/29/1997
  • Est. Priority Date: 10/14/1993
  • Status: Expired due to Term
First Claim
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1. A construct for generating a specific oligonucleotide within a cell, which construct comprises a nucleotide sequence from which the transcript is the specific oligonucleotide, said nucleotide sequence being flanked in the 5'"'"' direction by a stabilizing region and in the 3'"'"' direction by a termination sequence, and a promoter, which initiates transcription by RNA polymerase III, and which promoter is in the 5'"'"' direction from the stabilizing region.

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