Chemical compounds as inhibitors of amyloid beta protein production
First Claim
Patent Images
1. A compound of the formula ##STR5## in which Z is O or S;
- R11 is a halogen atom;
R12 is a halogen atom or a trifluoromethyl group;
X is S, SO, SO2, O or NH; and
R4 is naphthyl, quinolinyl, benzimidazolyl, pyridyl, pyridazinyl, benzoxazolyl or benzothiazolyl, unsubstituted or substituted by one or two substituents selected from a halogen atom, (1-4C)alkyl, (1-4C)alkoxy, nitro, (1-4C)alkoxycarbonyl, halo(1-4C)alkyl, and phenyl;
with the proviso that when R4 is pyridyl or pyridazinyl X must be S, SO, SO2 or NH;
or a pharmaceutically acceptable salt thereof.
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Abstract
A compound of the formula I in which ##STR1## Z is O or S; R11 is a halogen atom;
R12 is a halogen atom or a trifluoromethyl group; and
X is S, SO, SO2, O or NH;
R4 is naphthyl, quinolinyl, benzimidazolyl, pyridyl, pyradazinyl, benzoxazolyl or benzothiazolyl, unsubstituted or substituted by one or two substituents selected from a halogen atom, (1-4C)alkyl, (1-4C)alkoxy, nitro, (1-4C)alkoxycarbonyl, halo(1-4C)alkyl, and phenyl;
or a pharmaceutically acceptable salt thereof.
The compounds are useful as inhibitors of amyloid beta-protein production.
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Citations
12 Claims
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1. A compound of the formula ##STR5## in which Z is O or S;
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R11 is a halogen atom; R12 is a halogen atom or a trifluoromethyl group; X is S, SO, SO2, O or NH; and R4 is naphthyl, quinolinyl, benzimidazolyl, pyridyl, pyridazinyl, benzoxazolyl or benzothiazolyl, unsubstituted or substituted by one or two substituents selected from a halogen atom, (1-4C)alkyl, (1-4C)alkoxy, nitro, (1-4C)alkoxycarbonyl, halo(1-4C)alkyl, and phenyl; with the proviso that when R4 is pyridyl or pyridazinyl X must be S, SO, SO2 or NH; or a pharmaceutically acceptable salt thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A pharmaceutical composition which comprises a compound of the formula ##STR6## in which Z is O or S;
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R11 is a halogen atom; R12 is a halogen atom or a trifluoromethyl group; X is S, SO, SO2, O or NH; and R4 is naphthyl, quinolinyl, benzimidazolyl, pyridyl, pyridazinyl, benzoxazolyl or benzothiazolyl, unsubstituted or substituted by one or two substituents selected from a halogen atom, (1-4C)alkyl, (1-4C)alkoxy, nitro, 1-4C)alkoxycarbonyl, halo(1-4C)alkyl, and phenyl; or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable diluent or carrier. - View Dependent Claims (11, 12)
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Specification