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Modified oligonucleotides and intermediates useful in nucleic acid therapeutics

  • US 5,625,050 A
  • Filed: 03/31/1994
  • Issued: 04/29/1997
  • Est. Priority Date: 03/31/1994
  • Status: Expired due to Term
First Claim
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1. A modified oligonucleotide of between 12 and 60 bases having at least three consecutive 3'"'"'-hydroxymethylene modified internucleotide linkages of the structure:

  • ##STR11## wherein, R5 is a counterion, C1 and C2 represent the 3'"'"'-position and 5'"'"'-position, respectively, of the nucleoside units which are joined together in said oligonucleotide through said 3'"'"'-hydroxymethylene internucleotide linkages, and one of either X or Y is a hydroxyl (--OH--) group and the other of said X or Y is a hydrogen (--H--) atom.

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