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Transgenic non-human animals for producing heterologous antibodies

  • US 5,625,126 A
  • Filed: 12/07/1994
  • Issued: 04/29/1997
  • Est. Priority Date: 08/29/1990
  • Status: Expired due to Term
First Claim
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1. A transgenic mouse containing in its genome a transgene comprising in operable linkage a plurality of human V genes, a plurality of human D genes, a plurality of human J genes, a human μ

  • CH gene, at least two different non-μ

    human CH genes and associated isotype switching sequences, wherein human μ and

    human γ

    switch sequences are located in closer proximity to each other than in the naturally occurring human immunoglobulin locus; and

    wherein in lymphocytes of said mouse the transgene undergoes productive VDJ rearrangement and μ

    to γ

    isotype switching by recombination between the human μ and

    human γ

    switch sequences such that the mouse produces a serum containing immunoglobulins of at least three human heavy chain isotypes in response to antigenic stimulation.

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