Method and system for imaging objects in turbid media using diffusive fermat photons

• US 5,625,458 A
• Filed: 02/03/1995
• Issued: 04/29/1997
• Est. Priority Date: 11/10/1994
• Status: Expired due to Fees

• Current Assignee: City College of New York
• Original Assignee: The Research Foundation of State University of New York
• Inventors: Polishchuk, Alexander Y., Alfano, Robert R.
• Primary Examiner(s): Gonzalez, Frank
• Assistant Examiner(s): VIERRA EISENBERG, JASON D
• Application Number:
  US08/384,112
• Time in Patent Office: 816 Days
• Field of Search: 356/332-343, 356/446, 250/341.1, 250/358.1, 250/341.8, 178/673, 178/664-665
• US Class Current: 356/446
• CPC Class Codes: A61B 5/0042 for the brain
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

A method for imaging objects in turbid media. According to one embodiment of the invention, the method comprises the steps of (a) illuminating the object through the turbid medium with a pulse of light, the light emergent from the turbid medium consisting of a ballistic component, a snake-like component and a diffusive component, the diffusive component including Fermat photons and non-Fermat photons; (b) gating the light emergent from the turbid medium to preferentially select Fermat photons; and (c) forming an image of the object using the gated light. Preferably, a spatial gate is used to preferentially select Fermat photons from the emergent light. This may be done by orienting the source of the illuminating light and a light detector to lie along a most favorable path travelled predominately by Fermat photons. A time gate, such as a streak camera or the like, may be used in addition to the spatial gate to more carefully select Fermat photons from the emergent light. The above-described method may also be used to produce a tomography map of a turbid medium for use in detecting an object located within the turbid medium. This may be done, for example, by providing two or more pairs of light sources and light detectors which are arranged to provide intersecting most favorable paths. The present invention is also directed to systems constructed in accordance with the foregoing methods.

Claims

1. A method of imaging an object located in a turbid medium, said method comprising the steps of:

(a) illuminating the object through the turbid medium with a pulse of light, whereby light emerges from the turbid medium, the emergent light from the turbid medium consisting of a ballistic component, a snake-like component and a diffusive component, said diffusive component including Fermat photons and non-Fermat photons;

(b) gating the emergent light from the turbid medium to preferentially select Fermat photons; and

(c) forming an image of the object using the gated light.

2. The method as claimed in claim 1 wherein said gating step comprises spatially gating the emergent light from the turbid medium.

3. The method as claimed in claim 2 wherein said spatially gating step comprises emitting said pulse of light from a collimated source and positioning a collimated light detector along a most favorable path traveled by Fermat photons.

4. The method as claimed in claim 1 wherein said gating step comprises temporally gating and spatially gating the emergent light from the turbid medium.

5. The method as claimed in claim 4 wherein said spatially gating step comprises emitting said pulse of light from a collimated source and positioning a collimated light detector along a most favorable path traveled by Fermat photons.

6. The method as claimed in claim 5 wherein said temporally gating step comprises temporally resolving the light detected by said collimated light detector.

7. The method as claimed in claim 6 wherein said temporally gating step is performed using a streak camera.

8. The method as claimed in claim 1 wherein said pulse of light has a wavelength of about 800 nm to about 1500 nm.

9. The method as claimed in claim 1 wherein said pulse of light is an ultrashort pulse of light.

10. The method as claimed in claim 9 wherein said pulse of light is emitted from a laser selected from the group consisting of picosecond and femtosecond Ti:

Sapphire lasers, Forsterite lasers and Cr;

YAG lasers.

11. The method as claimed in claim 1 wherein said turbid medium is a biological tissue.

12. The method as claimed in claim 11 wherein said biological tissue is selected from the group consisting of human breast tissue, human brain tissue, human neck tissue and human prostate tissue and wherein said object is a tumor.

13. A system for imaging an object located in a turbid medium, said system comprising:

(a) means for illuminating the object through the turbid medium with a pulse of light, whereby light emerges from the turbid medium, the emergent light consisting of a ballistic component, a snake-like component and a diffusive component, said diffusive component including Fermat photons and non-Fermat photons;

(b) means for gating the emergent light from the turbid medium to preferentially select Fermat photons; and

(c) means for forming an image of the object using the gated light.

14. The system as claimed in claim 13 wherein said gating means comprises spatial gating means and temporal gating means.

15. The system as claimed in claim 14 wherein said spatial gating means comprises a collimated light detector positioned along a most favorable path traveled by Fermat photons, said collimated light detector having an output.

16. The system as claimed in claim 15 wherein said temporal gating means comprises a streak camera coupled to the output of said collimated light detector.

17. A method of generating a tomographic map of a turbid medium, said method comprising the steps of:

(a) illuminating the turbid medium with a first pulse of light, whereby light emerges from the turbid medium, the emergent light from the turbid medium consisting of a ballistic component, a snake component and a diffusive component, the diffusive component comprising Fermat photons and non-Fermat photons, at least some of the Fermat photons having traveled through the turbid medium along a first most favorable path;

(b) illuminating the turbid medium with a second pulse of light, whereby light emerges from the turbid medium, the emergent light from the turbid medium consisting of a ballistic component, a snake component and a diffusive component, the diffusive component comprising Fermat photons and non-Fermat photons, at least some of the Fermat photons having traveled through the turbid medium along a second most favorable path, said first most favorable path and said second most favorable path intersecting at a point within the turbid medium;

(c) gating the emergent light from the turbid medium attributable to said first pulse of light so as to preferentially select therefrom Fermat photons;

(d) gating the emergent light from the turbid medium attributable to said second pulse of light so as to preferentially select therefrom Fermat photons; and

(e) using the photons gated in steps (c) and (d) to generate a tomographic map of the turbid medium.

18. The method as claimed in claim 17 wherein said gating step of step (c) comprises positioning a collimated light detector to detect light traveling along said first most favorable path and wherein said gating step of step (d) comprises positioning a collimated light detector to detect light traveling along said second most favorable path.

19. The method as claimed in claim 18 wherein said gating step of step (c) further comprises temporally resolving the light detected by said collimated light detector to preferentially select Fermat photons and wherein said gating step of step (d) further comprises temporally resolving the light detected by said collimated light detector to preferentially select Fermat photons.

20. The method as claimed in claim 17 further comprising the steps of illuminating the turbid medium with one or more additional pulses of light, each of said additional pulses of light including Fermat photons which travel through the turbid medium along a most favorable path which intersects at least one of said first most favorable path and said second most favorable path within the turbid medium;

gating the emergent light from the turbid medium attributable to each of said additional pulses of light so as to preferentially select therefrom Fermat photons; and

using the gated Fermat photons from said additional pulses of light, together with the gated Fermat photons from steps (c) and (d), to generate a tomographic map of the turbid medium.

21. The method as claimed in claim 17 wherein each of said first and said second pulses of light has a wavelength of about 800 nm to about 1500 nm.

22. The method as claimed in claim 17 wherein each of said first and said second pulses of light is an ultrashort pulse of light.

23. The method as claimed in claim 22 wherein each of said first and said second pulses of light is emitted from a laser selected from the group consisting of picosecond and femtosecond Ti:

Sapphire lasers, Forsterite lasers and Cr;

YAG lasers.

24. The method as claimed in claim 17 wherein said turbid medium is a biological tissue.

25. The method as claimed in claim 24 wherein said biological tissue is selected from the group consisting of human breast tissue, human brain tissue, human neck tissue and human prostate tissue and wherein said object is a tumor.

26. A system for generating a tomographic map of a turbid medium, said system comprising:

(a) means for illuminating the turbid medium with a first pulse of light, whereby light emerges from the turbid medium, the emergent light from the turbid medium consists of a ballistic component, a snake component and a diffusive component, the diffusive component comprising Fermat photons and non-Fermat photons, at least some of the Fermat photons having traveled through the turbid medium along a first most favorable path;

(b) means for illuminating the turbid medium with a second pulse of light, whereby light emerges from the turbid medium, the emergent light from the turbid medium consists of a ballistic component, a snake component and a diffusive component, the diffusive component comprising Fermat photons and non-Fermat photons, at least some of the Fermat photons having traveled through the turbid medium along a second most favorable path, said first most favorable path and said second most favorable path intersecting at a point within turbid medium;

(c) means for gating the emergent light from the turbid medium attributable to said first pulse of light so as to preferentially select therefrom Fermat photons;

(d) means for gating the emergent light from the turbid medium attributable to said second pulse of light so as to preferentially select therefrom Fermat photons; and

(e) means for generating a tomographic map of the turbid medium using the Fermat photons detected in steps (c) and (d).