Method and apparatus for optimizing pacemaker AV delay

• US 5,626,623 A
• Filed: 04/30/1996
• Issued: 05/06/1997
• Est. Priority Date: 04/30/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Bennett, Tommy D., Kieval, Robert S.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US08/640,434
• Time in Patent Office: 371 Days
• Field of Search: 607/9, 607/14, 607/23, 607/24, 607/25
• US Class Current: 607/23
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

In a dual chamber cardiac pacemaker, a method and apparatus for determining an atrioventricular (AV) delay interval to maintain optimal left heart AV mechanical synchrony and function. When the intrinsic or paced atrial heart rate is stable, test AV delay intervals are selected and delivered as right ventricular absolute blood pressures (RVP) are measured at the opening of the pulmonary valve. The opening of the pulmonary valve is determined by the peak rate of change in the RVP (dP/dt) following depolarization of the right ventricle. The test AV delay interval providing the lowest amplitude RVP at the peak dP/dt, indicating the lowest pulmonary blood pressure, is selected as the optimal AV delay. The system may be fully contained in an implanted pacemaker system including a right ventricular absolute blood pressure sensor and automatically invoked to determine the optimum AV delay for the prevailing atrial heart rate at any time, or may be invoked at a predetermined time of day or may be invoked by a programmed-in command. The system may also be employed on a temporary basis in conjunction with an implanted dual chamber pacemaker and an external pacemaker programmer with a temporary absolute blood pressure sensor to provide the blood pressure signals.

Claims

1. In a dual chamber pacemaker pulse generator operating in accordance with an atrial-ventricular (AV) synchronous pacing method comprising the steps of:

timing a ventricular-atrial (V-A) pacing escape interval from a paced ventricular event;

delivering an atrial pace pulse to an atrium of a patient'"'"'s heart at the time out of the V-A pacing escape interval unless an atrial sensed event occurs within said pacing escape interval;

prematurely terminating the V-A pacing escape interval on the sensing of an atrial sensed event within said V-A pacing escape interval;

timing an AV delay interval starting from a sensed atrial event or delivery of an atrial pace pulse;

delivering a ventricular pace pulse to a ventricle of the patient'"'"'s heart at the termination of the AV delay interval unless a ventricular sensed event occurs within the AV delay interval;

prematurely terminating the AV delay interval on the sensing of a ventricular sensed event within the AV delay interval; and

restarting the V-A pacing escape interval on a ventricular pace pulse or a ventricular sensed event,

an AV delay interval optimization method for establishing an optimum AV delay interval for optimal left heart AV mechanical synchrony and function operable in conjunction with the AV synchronous pacing method steps comprising the further optimization method steps of;

(a) determining a stable atrial heart rate;

(b) on determination of a stable heart rate in step (a), continuing with steps (c)-(i) with an initial test AV delay interval;

(c) in the time period following a ventricular pace pulse delivered at the end of the initial test AV delay interval, measuring right ventricular blood pressure and providing a right ventricular pressure (RVP) signal;

(d) deriving a pressure rate of change signal (dP/dt) from the measured RVP signal;

(e) determining a peak amplitude of the dP/dt signal;

(f) measuring the RVP signal amplitude at the determined peak dP/dt signal as an estimated Pulmonary Artery Diastolic (EPAD) pressure;

(g) repeating steps (c)-(f) while a stable atrial heart rate continues with a set of adjusted test AV delay intervals changed by a predetermined delta value between a minimum and a maximum AV delay interval to derive a set of EPAD pressure values;

(h) identifying the test AV delay interval providing the lowest amplitude EPAD pressure value; and

(i) selecting the identified test AV delay interval as the AV delay interval employed in the A-V synchronous pacing method.

2. The optimization method of claim 1 wherein said pacemaker pulse generator comprises means for programming operating modes thereof in response to programmed-in commands from an external programmer, and said optimization method further comprises the step of:

initiating said optimization method with a programmed-in command from said external pacemaker programmer.

3. The optimization method of claim 1 wherein said pacemaker pulse generator comprises timing means for providing a time of day, and said optimization method further comprises the step of:

initiating said optimization method at a predetermined time of day.

4. The optimization method of claim 1 wherein said pacemaker pulse generator comprises memory for storing AV delay intervals, and said optimization method further comprises the steps of:

measuring the stable atrial heart rate determined in step (a); and

storing the test AV delay identified in step (h) in relation to the measured stable heart rate in memory;

and wherein the AV synchronous pacing method further comprises the step of retrieving from memory and employing the stored AV delay intervals corresponding to the V-A escape interval in timing the AV delay interval.

5. The optimization method of claim 4 wherein the AV synchronous pacing method further comprises:

determining a physiologic need for cardiac output from a rate control parameter;

establishing said V-A escape interval and said AV delay interval as a function of the determined physiologic need for cardiac output.

6. The optimization method of claim 1 wherein the AV synchronous pacing method further comprises:

determining a physiologic need for cardiac output from a rate control parameter;

establishing said V-A escape interval and said AV delay interval as a function of the determined physiologic need for cardiac output between a pacing lower rate and a pacing upper rate limit.

7. The optimization method of claim 1 further comprising the step of terminating the optimization method on the premature termination of the test AV delay interval by a ventricular sensed event.

8. In a dual chamber pacemaker, operating in accordance with the AV synchronous method comprising the steps of:

timing an escape interval from a paced or sensed ventricular event;

delivering an atrial pace pulse to an atrial chamber of a patient'"'"'s heart at the termination of the escape interval unless an atrial sensed event occurs within said escape interval;

prematurely terminating said escape interval on the sensing of an atrial sensed event within said escape interval

timing an atrial-ventricular (AV) delay interval from said sensed atrial event;

delivering a ventricular pace pulse to a ventricular chamber of the patient'"'"'s heart at the termination of the AV delay interval unless a ventricular sensed event occurs within said AV delay interval; and

restarting said escape interval on a ventricular pace pulse or a ventricular sensed event;

an AV delay interval optimization method for establishing an optimum AV delay interval for optimal left heart AV mechanical synchrony and function comprising the further steps of;

determining a stable atrial heart rate from a series of regular escape intervals;

in the AV delay test mode and in each of a succeeding series of regular escape intervals,

selecting a test AV delay interval varying between a maximum AV delay interval and a minimum AV delay interval; and

in the escape interval following the ventricular pace pulse delivered at the end of the test AV delay interval, determining the opening of the pulmonary valve and measuring right ventricular absolute blood pressure level at the moment of opening of the pulmonary valve;

identifying the AV delay interval providing the lowest measured ventricular absolute blood pressure level at the opening of the pulmonary heart valve; and

selecting the identified AV delay interval as the AV delay interval associated with the intrinsic atrial depolarization rate of the heart.

9. The method of claim 8 wherein the step of determining the opening of the pulmonary valve following a ventricular sensed event or ventricular pace pulse further comprises:

processing the absolute pressure signal and providing a pressure rate of change signal; and

determining a peak of the pressure rate of change signal signifying the slowing of the increase of the absolute pressure signal occurring on opening of the pulmonary valve.

10. The method of claim 8 wherein the step of determining a stable atrial heart rate from a series of regular escape intervals further comprises the steps of:

measuring the elapsed escape interval time to a premature termination by a sensed atrial event; and

determining the occurrence a series of regular elapsed escape intervals terminating with an atrial sense event to commence an AV delay test mode.

11. In a dual chamber pacemaker operating in an atrial-ventricular (AV) synchronous pacing mode at a pacing rate dependent on a ventricular-atrial (V-A) pacing escape interval and an intrinsic V-A interval, an optimization method of establishing a set of optimized atrial-ventricular (AV) delay intervals for a corresponding set of V-A pacing escape intervals or intrinsic V-A intervals in a range between lower and upper pacing rate limits, each AV delay interval timed between a sensed or paced atrial event and a ventricular pace pulse delivered in the absence of a ventricular sensed event occurring during the AV delay interval, the optimization method comprising the steps of:

(a) from a preceding ventricular paced event, measuring the intrinsic V-A interval of a series of atrial sensed events;

(b) from the measured series of intrinsic V-A intervals, determining that the atrial heart rate is stable within a certain range and then continuing with steps (c) to (j);

(c) selecting a test AV delay interval;

(d) sensing right ventricular absolute pressure following a ventricular pace pulse at the end of the AV delay interval and providing an absolute pressure signal;

(e) determining the opening of the pulmonary valve from a characteristic change in the absolute pressure signal;

(f) measuring the absolute pressure signal level at the determined opening of the pulmonary valve;

(g) repeating steps (c)-(f) with a series of adjusted test AV delay intervals between a maximum AV delay interval and a minimum AV delay interval;

(h) comparing the absolute pressure signal levels measured in step (f);

(i) identifying the test AV delay interval providing the lowest measured absolute blood pressure level; and

(j) selecting the identified AV delay interval as the AV delay interval associated with the atrial escape interval.

12. The optimization method of claim 11 wherein the step of determining the opening of the pulmonary valve further comprises:

processing the absolute pressure signal and providing a pressure rate of change signal; and

determining a peak of the pressure rate of change signal signifying the slowing of the increase of the absolute pressure signal occurring on opening of the pulmonary valve.

13. The optimization method of claim 11 wherein said pacemaker pulse generator comprises means for programming operating modes thereof in response to programmed-in commands from an external programmer, and said optimization method further comprises the step of:

initiating said optimization method with a programmed-in command from said external pacemaker programmer.

14. The optimization method of claim 11 wherein said pacemaker pulse generator comprises timing means for providing a time of day, and said optimization method further comprises the step of:

initiating said optimization method at a predetermined time of day.

15. The optimization method of claim 11 wherein the AV synchronous pacemaker pulse generator further comprises:

means for determining a physiologic need for cardiac output from a rate control parameter; and

means for establishing said V-A escape interval and said AV delay interval as a function of the determined physiologic need for cardiac output.

16. The optimization method of claim 11 further comprising the step of terminating the optimization method on the premature termination of the test AV delay interval by a ventricular sensed event.

17. The optimization method of claim 11 wherein step (b) further comprises:

determining a stable atrial heart rate from a series of timed out V-A pacing escape intervals or a series of atrial sensed events terminating V-A pacing escape intervals at a stable intrinsic interval from the preceding ventricular pace or sensed event.

18. In a dual chamber pacemaker pulse generator operable in an atrial-ventricular (AV) synchronous mode of the type having:

means for sensing atrial depolarizations of the heart and providing atrial sensed events;

means for sensing ventricular depolarizations of the heart and providing ventricular sensed events;

means for generating ventricular pace pulses on the time-out of an AV delay interval;

means for terminating the AV delay on sensing a ventricular depolarization during the time out of the AV delay interval;

means for timing a ventricular-atrial (V-A) pacing escape interval from a ventricular sensed event or generation of a ventricular pace pulse that may be terminated by an atrial sensed event; and

means for generating atrial pace pulses at the termination of the V-A pacing escape interval;

the improvement in apparatus for optimizing the AV delay interval for a given atrial heart rate as a function of pulmonary blood pressure level to ensure optimum timing of ventricular pacing pulses and optimum AV mechanical synchrony in the left heart further comprising;

means for determining the occurrence of a regular atrial heart rate;

means for adjusting the length of said AV delay interval;

means operable following delivery of a pacing pulse at the end of the adjusted AV delay interval for measuring right ventricular absolute blood pressure during said pacing escape interval;

means for determining the adjusted AV delay interval providing the lowest right ventricular absolute blood pressure at the moment of opening of the pulmonary valve; and

means for selecting said determined AV delay interval for use with said given pacing escape interval in the AV synchronous mode of the pacemaker pulse generator.

19. In a dual chamber pacemaker operating in an atrial-ventricular (AV) synchronous pacing mode at a pacing rate dependent on a ventricular-atrial (V-A) pacing escape interval and an intrinsic V-A interval, an optimization system for establishing an optimized atrial-ventricular (AV) delay interval for a corresponding V-A pacing escape intervals or intrinsic V-A interval in a range between lower and upper pacing rate limits, each AV delay interval timed between a sensed or paced atrial event and a ventricular pace pulse delivered in the absence of a ventricular sensed event occurring during the AV delay interval, the system comprising:

means for determining that the atrial heart rate is stable within a certain range;

means for selecting a test AV delay interval from among a plurality of test AV delay intervals within a range between a maximum test AV delay interval and a minimum test AV delay interval;

means for sensing right ventricular absolute pressure within the right ventricle following a ventricular pace pulse at the end of the AV delay interval and providing an absolute pressure signal;

means for determining the moment of opening of the pulmonary valve from a characteristic change in the absolute pressure signal;

means for measuring the absolute pressure signal level at the determined moment of opening of the pulmonary valve;

means operable while the heart rate remains stable for measuring a plurality of absolute pressure values at the determined moments of opening of the pulmonary valve in relation to said plurality of test AV delay intervals within said range between said maximum and minimum test AV delay intervals;

means for identifying the test AV delay interval within said range providing the lowest measured absolute blood pressure level; and

means for selecting the identified AV delay interval as the AV delay interval associated with the atrial escape interval.

20. The optimization system of claim 19 wherein the means for determining the moment of opening of the pulmonary valve further comprises:

means for processing the absolute pressure signal and providing a pressure rate of change signal; and

means for determining a peak of the pressure rate of change signal signifying the slowing of the increase of the absolute pressure signal occurring on opening of the pulmonary valve.

21. The optimization system of claim 19 wherein said pacemaker pulse generator comprises means for programming operating modes thereof in response to programmed-in commands from an external programmer, and said optimization system further comprises:

means for initiating said optimization method with a programmed-in command from said external pacemaker programmer.

22. The optimization system of claim 19 wherein said pacemaker pulse generator comprises timing means for providing a time of day, and said optimization system further comprises:

means for initiating said optimization method at a predetermined time of day.

23. The optimization system of claim 19 wherein said pacemaker pulse generator further comprises:

means for determining a physiologic need for cardiac output from a rate control parameter; and

means for establishing said V-A escape interval and said AV delay interval as a function of the determined physiologic need for cardiac output.

24. The optimization system of claim 19 further comprising means for terminating the optimization method on the premature termination of the test AV delay interval by a ventricular sensed event.

25. The optimization system of claim 19 wherein said stable heart rate determining means further comprises:

means for determining a stable atrial heart rate from a series of timed out V-A pacing escape intervals or a series of atrial sensed events terminating V-A pacing escape intervals at a stable intrinsic interval from the preceding ventricular pace or sensed event.

26. The optimization system of claim 19 wherein said stable heart rate determining means further comprises:

means for measuring the intrinsic V-A interval of a series of atrial sensed events following a series of ventricular pace pulses; and

means for determining that the atrial heart rate is stable within a certain range from the measured series of intrinsic V-A intervals.

27. The optimization system of claim 19 wherein said pacemaker pulse generator comprises downlink telemetry means responsive to programmed-in commands from an external programmer, and said optimization system further comprises:

means for initiating said optimization method with a programmed-in command from said external pacemaker programmer; and

means for selecting the maximum and minimum test AV delay intervals in response to programmed in commands from said external pacemaker programmer to provide a wide range of absolute pressure measurements to distinguish local minimum pressure values from true minimum pressure values among said plurality of absolute pressure values.

28. The optimization system of claim 27 wherein:

said system pacemaker pulse generator comprises means for providing uplink telemetry of said test AV delay intervals and said measured absolute blood pressure levels to said external programmer; and

said external programmer further comprises means for displaying said telemetered absolute pressure values in relation to said range of test AV delay intervals.