Blood treatment device with moving membrane

• US 5,626,759 A
• Filed: 08/01/1994
• Issued: 05/06/1997
• Est. Priority Date: 08/01/1994
• Status: Expired due to Fees

• Current Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Original Assignee: The Board of Regents of the University of Colorado (University of Colorado System)
• Inventors: Voorhees, Marc E., Elgas, Roger J., Bilodeau, Robert R., Krantz, William B.
• Primary Examiner(s): BHAT, NINA NMN
• Application Number:
  US08/284,057
• Time in Patent Office: 1,009 Days
• Field of Search: 422/46, 422/48, 210/321.4, 210/321.67, 210/645, 210/649, 128/DIG. 3, 95/46
• US Class Current: 210/645
• CPC Class Codes: A61M 1/1627 Dialyser of the inside perfusion type, i.e. blood flow inside hollow membrane fibres or tubes
• CPC Class Codes: A61M 1/1698 Blood oxygenators with or without heat-exchangers intracorporal A61M1/1678; manufacturing of membranes therefor B01D67/00; semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi-permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 1/26 and internal elements which are moving
• CPC Class Codes: A61M 1/3623 Means for actively controlling temperature of blood
• CPC Class Codes: B01D 63/16 Rotary, reciprocated or vibrated modules

Abstract

A medical device and method for affecting mass transfer between blood and a fluid. In one application, this mass transfer is an oxygenation of the blood. Generally, a membrane which separates the blood and fluid is moved in a predetermined manner and in a direction which is substantially parallel to that of the primary direction of the flow to augment the mass transfer efficiency/rate. Importantly, this movement of the membrane is relative to the blood mass transfer boundary layer which steepens or increases the oxygen concentration gradient and decreases the thickness of the blood mass transfer boundary layer and thereby improves upon the mass transfer efficiency/rate of oxygen into the blood.

Claims

1. A method for affecting mass transfer between a fluid and blood, comprising the steps of:

separating a flow of blood and a flow of fluid with a membrane;

moving an entirety of said membrane relative to at least one mass transfer boundary layer associated with at least one of the flow of blood and the flow of fluid in a direction which is substantially parallel with a primary direction of at least one of the flow of blood and the flow of fluid; and

transferring at least one component of at least one of the blood and the fluid through said membrane.

2. A method, as claimed in claim 1, wherein:

said moving step comprises using a symmetrical driving signal.

3. A method, as claimed in claim 1, wherein:

said moving step comprises using an asymmetrical driving signal.

4. A method, as claimed in claim 1, wherein:

said moving step comprises moving said membrane between first and second positions in a predetermined pattern comprising pausing for a predetermined period of time at least at one of said first position, said second position, and an intermediate position between said first and second positions.

5. A method, as claimed in claim 1, wherein:

said moving step comprises axially reciprocating said membrane between first and second positions.

6. A method, as claimed in claim 1, wherein:

said membrane defines at least a portion of a conduit for the flow of blood, wherein said method further comprises the step of at least one of increasing and decreasing the flow of blood out of said conduit during a least a portion of said moving step.

7. A method, as claimed in claim 6, wherein:

said increasing the flow step comprises increasing a volume of an outlet conduit connected to said conduit.

8. A method, as claimed in claim 1, further comprising the step of:

providing a counterflow of at least one of blood and fluid during at least a portion of said moving step.

9. A method, as claimed in claim 1, further comprising the steps of:

using an input signal to control said moving step; and

selecting at least one of a wave form, an amplitude, and a frequency of said input signal.

10. A method, as claimed in claim 1, further comprising the step of:

generating substantially only shear forces between the mass transfer boundary layer and said membrane during said moving step.

11. A method, as claimed in claim 1, further comprising the step of:

reducing the resistance c,f the blood mass transfer boundary layer using substantially only said moving step.

24. A device, as claimed in claim 1, further comprising:

means for driving said means for moving and means for selecting at least one of a wave form, a frequency, and an amplitude for said means for driving.

12. A medical device for affecting mass transfer between blood and a fluid, comprising:

a housing;

at least one membrane disposed within said housing and having first and second sides, said membrane being permeable with respect to at least one component of at least one of the blood and the fluid;

a blood inlet fluidly interconnected with a space interfacing with said first side of said at least one membrane;

a fluid inlet fluidly interconnected with a space interfacing with said second side of said at least one membrane; and

means for moving an entirety of said membrane, in a direction which is substantially parallel with a primary direction of at least one of said flow of blood and said flow of fluid, relative to at least one mass transfer boundary layer.

13. A device, as claimed in claim 12, wherein:

said at least one membrane comprises a substantially axially extending tube.

14. A device, as claimed in claim 12, further comprising:

a plurality of said membranes, wherein each said membrane comprises a substantially axially extending tube and wherein said plurality of tubes are disposed substantially parallel to each other, wherein one of said flow of blood and said flow of fluid is provided through said plurality of tubes and the other of said flow of blood and said flow of fluid is through at least a space between said plurality of tubes and said housing.

15. A device, as claimed in claim 14, wherein:

said plurality of tubes are spaced from each other, wherein said other of said flow of blood and said flow of fluid passes in a space between said tubes.

16. A device, as claimed in claim 12, wherein:

said at least one membrane is configured to provide for a substantially uniform flow of blood thereby having a flow field defined by substantially straight and parallel streamlines.

17. A device, as claimed in claim 12, wherein:

said at least one membrane comprises a substantially planar sheet.

18. A device, as claimed in claim 12, wherein:

said at least one membrane comprises a pleated sheet.

19. A device, as claimed in claim 12, wherein:

one of said blood inlet and said fluid inlet comprises an input manifold, said device further comprising;

a first variable volume connector positioned between and interconnecting a first end of said housing and said input manifold;

an output manifold; and

a second variable volume connector positioned between and interconnecting a second end of said housing, opposite said first end, and said output manifold, wherein said at least one membrane is fixedly interconnected with said housing and wherein said means for moving said at least one membrane comprises said first and second variable volume connectors.

20. A device, as claimed in claim 19, wherein:

said first and second variable volume connectors each comprise a bellows.

21. A device, as claimed in claim 19, wherein:

said first and second variable volume connectors each comprise a telescoping connector.

22. A device, as claimed in claim 12, wherein:

the fluid comprises oxygen.

23. A device, as claimed in claim 12, wherein:

said means for moving comprises means for reciprocating said at least one membrane between first and second positions.

25. A device, as claimed in claim 12, further comprising:

means for driving said means for moving, said means for driving providing a symmetrical signal to said means for moving.

26. A device, as claimed in claim 12, further comprising:

means for driving said means for moving, said means for driving providing an asymmetrical signal to said means for moving.

27. A device, as claimed in claim 12, wherein:

said means for moving moves said at least one membrane between first and second positions, said device further comprising means for driving said means for moving, said means for driving causing said at least one membrane to pause for a predetermined period of time at least at one of said first position, said second position and an intermediate position between said first and second positions.

28. A device, as claimed in claim 12, further comprising:

an outlet conduit connected to said housing and fluidly connected with said flow of blood on said first side of said membrane, wherein said means for moving comprises means for accommodating at least one of an increase or a decrease in a magnitude of said flow of blood out of said housing during at least a portion of a movement of said at least one membrane provided by said means for moving.

29. A device, as claimed in claim 28, wherein:

said means for accommodating comprises a variable volume connector positioned between and interconnecting said outlet conduit and said housing.

30. A device, as claimed in claim 12, further comprising:

means for controlling an amount of mass transfer between the fluid and the blood.

31. A device, as claimed in claim 12, further comprising:

means for pulsing at least one of said flow of blood past said first side of said at least one membrane and said flow of fluid past said second side of said at least one membrane.

32. A device, as claimed in claim 12, further comprising:

means for passively augmenting the mass transfer between the blood and fluid.

33. A device, as claimed in claim 12, further comprising:

means for establishing a counterflow of blood on said first side of said at least one membrane.

34. A device, as claimed in claim 12, further comprising:

a substantially stationary inlet conduit;

first means for interconnecting said inlet conduit and said housing, said first means allowing said at least one membrane to move relative to said inlet conduit;

a substantially stationary outlet conduit; and

second means for interconnecting said outlet conduit and said housing, said second means allowing said at least one membrane to move relative to said outlet conduit.

35. A device, as claimed in claim 12, further comprising:

at least one substantially stationary conduit; and

means for interconnecting said stationary conduit and said housing, said means for interconnecting allowing said at least one membrane to move relative to said stationary conduit.

36. A device, as claimed in claim 35, further comprising:

means for establishing a counterflow of blood on said first side of said at least one membrane.

37. A device, as claimed in claim 36, wherein:

said means for establishing comprises at least one member positioned in said stationary conduit, said at least one member being disposed in a non-parallel position relative to a primary direction of said flow of blood past said first side of said at least one membrane.

38. A device, as claimed in claim 12, wherein:

said means for moving comprises means for generating substantially only a shear force between said at least one membrane and a portion of said flow of blood adjacent said at least one membrane.

39. A device, as claimed in claim 12, wherein:

said means for moving comprises first and second telescoping connectors interconnected with first and second ends of said housing, respectively.

40. A device, as claimed in claim 12, wherein:

said means for moving comprises at least one telescoping connector interconnected with said housing.