Integrin-binding peptides

• US 5,627,263 A
• Filed: 04/18/1995
• Issued: 05/06/1997
• Est. Priority Date: 11/24/1993
• Status: Expired due to Term

• Current Assignee: La Jolla Cancer Research Foundation
• Original Assignee: La Jolla Cancer Research Foundation
• Inventors: Ruoslahti, Erkki, Koivunen, Erkki
• Primary Examiner(s): Weimar, Elizabeth C.
• Assistant Examiner(s): Gupta, Anish
• Application Number:
  US08/425,238
• Time in Patent Office: 749 Days
• Field of Search: 530/327, 530/328, 530/329, 514/14, 514/15, 514/16
• US Class Current: 530/327
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: C07K 14/70546 Integrin superfamily
• CPC Class Codes: C07K 14/75 Fibrinogen
• CPC Class Codes: C07K 14/78 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Abstract

The present invention provides peptides having specificity for fibronectin-binding and vitronectin-binding integrins, and in particular for α₅ β₁ integrin. These peptides are characterized by having the ability to interfere with fibronectin binding to α₅ β₁ integrin, to block attachment of cells expressing integrins to extracellular matrix proteins and to promote cell attachment when immobilized onto a surface.

Claims

1. A peptide whose amino acid sequence is GACRRETAWACGA [SEQ ID NO:

3].

2. A peptide whose amino acid sequence is CRRETAWAC [SEQ ID NO:

6].