Ultrasonic techniques for neurostimulator control

• US 5,628,317 A
• Filed: 04/04/1996
• Issued: 05/13/1997
• Est. Priority Date: 04/04/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Rise, Mark T., Starkebaum, Warren
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): FIELDS, DERRICK LAMAR
• Application Number:
  US08/627,574
• Time in Patent Office: 404 Days
• Field of Search: 607/49, 607/56, 607/48, 128/660.03, 128/662.05, 128/662.06
• US Class Current: 600/437
• CPC Class Codes: A61B 8/0858 involving measuring tissue layers, e.g. skin, interfaces
• CPC Class Codes: A61N 1/36071 Pain

Abstract

A lead adapted to be implanted adjacent a spinal cord located within a spinal column of a vertebrate in order to facilitate stimulation of the spinal cord or adjacent tissue. An ultrasonic transmitter/receiver produces an ultrasonic sound wave that creates ultrasonic echo waves reflected from a predetermined portion of the spinal cord and generates a distance signal related to the distance between the transducer/receiver and the predetermined portion of the spinal cord. The distance signal is used to adjust the amplitude of an electrical stimulation signal that stimulates the spinal cord or adjacent tissue so that the value of the stimulation signal tends to remain uniform in spite of changes in the relative distance between the transducer/receiver and the predetermined portion of the spinal cord.

Claims

1. Apparatus for stimulation of a spinal cord or tissue adjacent a spinal cord located within the spinal column of a vertebrate comprising in combination:

ultrasonic transducer means adapted to be implanted adjacent said spinal cord for producing ultrasonic sound waves that create ultrasonic echo waves reflected from a predetermined portion of said spinal cord and for generating a distance signal in response to said ultrasonic echo waves, a value of said distance signal being related to a distance between said transducer means and said predetermined portion of said spinal cord;

a stimulation driver for generating a stimulation signal;

a drive amplifier responsive to said stimulation signal and said distance signal for generating a drive signal that increases in value as the distance between said transducer means and said predetermined portion increases, and decreases in value as the distance between said transducer means and said predetermined portion decreases;

at least one stimulation electrode adapted to be implanted adjacent said spinal cord; and

means for transmitting said drive signal to said at least one electrode, whereby the uniformity of stimulation received by said spinal cord or adjacent tissue is increased in spite of changes in the relative distance between said transducer means and said predetermined portion of said spinal cord.

2. Apparatus, as claimed in claim 1, wherein said ultrasonic transducer means comprises:

a drive circuit for generating an ultrasonic drive signal;

an ultrasonic transmitter for producing said ultrasonic sound waves in response to said ultrasonic drive signal;

an ultrasonic receiver for generating said distance signal in response to said ultrasonic echo waves.

3. Apparatus, as claimed in claim 2, wherein said ultrasonic transmitter is operated continuously and wherein said ultrasonic receiver produces said distance signal by responding to an amplitude of the echo waves received by said ultrasonic receiver.

4. Apparatus, as claimed in claim 2, wherein said first ultrasonic transmitter is pulsed and wherein said ultrasonic receiver produces said distance signal by responding to a time delay between a production of a pulse by said ultrasonic transmitter and a receipt of a corresponding echo wave by said ultrasonic receiver.

5. Apparatus, as claimed in claim 2, wherein said receiver comprises:

an ultrasonic transducer for generating an electrical ultrasonic signal in response to said ultrasonic echo waves;

an amplifier for amplifying said ultrasonic signal to produce an amplified ultrasonic signal; and

filter means responsive to said amplified ultrasonic signal for generating said distance signal by minimizing the components of said amplified ultrasonic signal resulting from ultrasonic waves reflected from objects other than said predetermined portion of said spinal cord.

6. Apparatus, as claimed in claim 1, wherein said drive amplifier comprises a first input and a second input and further comprising means for impressing said drive signal between said first and second inputs and for transmitting said distance signal to said second input so that said distance signal provides negative feedback to said drive amplifier.

7. Apparatus, as claimed in claim 1, and further comprising means accessible from outside said driver or drive amplifier for adjusting the amplitude of said drive signal.

8. A method for stimulation of a spinal cord or tissue adjacent a spinal cord located within the spinal column of a vertebrate by means of a transducer and one or more stimulation electrodes implanted adjacent said spinal cord comprising the steps of:

producing ultrasonic sound waves that create ultrasonic echo waves reflected from a predetermined portion of said spinal cord;

generating a distance signal in response to said ultrasonic echo waves, a value of said distance signal being related to a distance between said transducer and said predetermined portion of said spinal cord;

generating a stimulation signal;

generating a drive signal responsive to said stimulation signal and said distance signal, said drive signal increasing in value as the distance between said transducer and said predetermined portion increases, and decreasing in value as the distance between said transducer and said predetermined portion decreases; and

transmitting said drive signal to said at least one stimulation electrode, whereby the uniformity of stimulation received by said spinal cord or adjacent tissue is increased in spite of changes in the relative distance between said transducer and said predetermined portion of said spinal cord.

9. A method, as claimed in claim 8, wherein said step of producing ultrasonic sound waves comprises:

generating an ultrasonic drive signal; and

producing said ultrasonic sound waves in response to said ultrasonic drive signal.

10. A method, as claimed in claim 9, wherein said step of generating an ultrasonic drive signal comprises the step of generating said drive signal continuously and wherein said step of generating said distance signal comprises the step of responding to an amplitude of said echo waves.

11. A method, as claimed in claim 9, wherein said step of generating an ultrasonic drive signal comprises the step of generating a pulse signal and wherein said step of generating said distance signal comprises the step of responding to a time delay between a production of said pulse signal and a receipt of a corresponding echo wave.

12. A method, as claimed in claim 11, wherein said step of generating said distance signal comprises the step of generating a time window during a time period in which said corresponding echo wave is received by said transducer so that an effect of echo waves received outside said time window is minimized.