Method and device for long-term delivery of drugs
First Claim
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1. An implant device for the long term delivery of a therapeutic agent to a tissue or organ, comprising:
- a container for implantation within the tissue or organ; and
a therapeutic agent immobilized in a biodegradable matrix wherein said matrix is biodegradable by enzymatic or acid/base hydrolysis and contained within the container such that the therapeutic agent is released at a rate of at least approximately 0.1 μ
g/day over a period of at least approximately one month, said device having a diameter of between approximately 20 microns and approximately 3 cm.
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Abstract
The present invention is an implantable device that is capable of delivering a therapeutic agent to a tissue or organ over a long period of time. The implantable device is especially suited for treating tissues and organs that are comprised of smooth muscle. The implantable device can deliver either a single therapeutic agent or a plurality of therapeutic agents to the tissue or organ at zero order kinetics.
350 Citations
24 Claims
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1. An implant device for the long term delivery of a therapeutic agent to a tissue or organ, comprising:
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a container for implantation within the tissue or organ; and a therapeutic agent immobilized in a biodegradable matrix wherein said matrix is biodegradable by enzymatic or acid/base hydrolysis and contained within the container such that the therapeutic agent is released at a rate of at least approximately 0.1 μ
g/day over a period of at least approximately one month, said device having a diameter of between approximately 20 microns and approximately 3 cm. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of treating a tissue or organ comprising the step of implanting an implant device into the tissue or organ, the implant device comprising:
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a container for implantation within the tissue or organ; and a therapeutic agent immobilized in a biodegradable matrix wherein said matrix is biodegradable by enzymatic or acid/base hydrolysis and contained within the container such that the therapeutic agent is released at a rate of at least approximately 0.1 μ
g/day over a period of at least approximately one month, said device having a diameter of between approximately 20 microns and approximately 3 cm. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification