Peptide related to human programmed cell death and DNA encoding it

• US 5,629,204 A
• Filed: 03/01/1995
• Issued: 05/13/1997
• Est. Priority Date: 03/01/1994
• Status: Expired due to Term

• Current Assignee: Kan'Yuchi, ONO Pharmaceutical Company Limited
• Original Assignee: ONO Pharmaceutical Company Limited, Tasuku Honjo
• Inventors: Ishida, Yasumasa, Shinohara, Takashi, Honjo, Tasuku
• Primary Examiner(s): Wax, Robert A.
• Assistant Examiner(s): BUGAISKY, GABRIELE E
• Application Number:
  US08/396,650
• Time in Patent Office: 804 Days
• Field of Search: 536/23.5, 536/24.31, 536/24.33, 435/69.1, 435/320.1, 435/240.1, 435/252.33, 435/254.11
• US Class Current: 435/320.1
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 14/70503 Immunoglobulin superfamily
• CPC Class Codes: C07K 2319/00 Fusion polypeptide

Abstract

A membrane protein related to human programmed cell death (PD-1) and DNA encoding the said protein is provided. PD-1 protein may be useful for the treatment of various infections, immunological depression or acceleration, or tumors etc.

Claims

1. An isolated DNA molecule encoding a polypeptide having the amino acid sequence shown in SEQ ID NO:

1.

2. The isolated DNA molecule according to claim 1, wherein said DNA molecule has the nucleotide sequence shown in SEQ ID NO:

2.

3. The isolated DNA molecule according to claim 1, wherein said DNA molecule has the nucleotide sequence in SEQ ID NO:

3.

4. A cloning vector comprising the isolated DNA molecule according to any of claims 1 to 3 operatively linked to an expression control sequence.