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Methods for forming an optical device for detecting the presence or amount of an analyte

  • US 5,629,214 A
  • Filed: 05/31/1995
  • Issued: 05/13/1997
  • Est. Priority Date: 09/18/1989
  • Status: Expired due to Term
First Claim
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1. A method for forming an optical device for detecting the presence or amount of an analyte of interest comprising:

  • a substrate which supports an optically active layer, comprising an optical thin film,an attachment layer provided on said optically active layer, wherein said attachment layer comprises a material selected from the group consisting of dendrimers, star polymers, molecular self-assembling polymers, polymeric siloxanes, and film forming latexes, anda receptive layer specific for said analyte provided on said attachment layer, said method comprising the steps of;

    forming said optical thin film with a chosen refractive index on said substrate by curing the optical thin film on the substrate at a controlled temperature or for a controlled length of time such that said optically active layer in conjunction with said attachment and receptive layers exhibits a first color in response to light impinging thereon, and exhibits a second color comprising a combination of wavelengths of light different from said first color or comprising an intensity of at least one said wavelength different from said first color, in response to said light when said analyte is present on said receptive layer; and

    subsequently providing said attachment and receptive layers on said optically active layer.

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