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Aqueous ophthalmic sprays

  • US 5,630,793 A
  • Filed: 03/23/1995
  • Issued: 05/20/1997
  • Est. Priority Date: 03/25/1994
  • Status: Expired due to Term
First Claim
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1. A method for administering a liquid ophthalmic formulation to the surface of the eye, said method comprising the steps of:

  • providing a spray nozzle having a liquid outlet in proximity to but spaced from said surface, said nozzle being situated adjacent to a piezoelectric or electromagnetic transducer;

    providing to said nozzle said liquid ophthalmic formulation comprising an ophthalmologically-acceptable liquid having a viscosity in the range 10-3 to 1.0 Pa.s and a resistivity lower than 104 ohm.cm;

    ejecting a jet of said formulation from said spray nozzle towards said surface, forming a stream of uniformly-sized, equally spaced, uncharged droplets by means of said transducer; and

    causing said droplets, upon formation, to pass through the charging field of a charging electrode, thereby inducing an electric charge on each droplet before contacting said surface;

    whereby the charged droplets discharge their electric charge by earthing on contact with the surface of said eye.

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