Aqueous ophthalmic sprays
First Claim
1. A method for administering a liquid ophthalmic formulation to the surface of the eye, said method comprising the steps of:
- providing a spray nozzle having a liquid outlet in proximity to but spaced from said surface, said nozzle being situated adjacent to a piezoelectric or electromagnetic transducer;
providing to said nozzle said liquid ophthalmic formulation comprising an ophthalmologically-acceptable liquid having a viscosity in the range 10-3 to 1.0 Pa.s and a resistivity lower than 104 ohm.cm;
ejecting a jet of said formulation from said spray nozzle towards said surface, forming a stream of uniformly-sized, equally spaced, uncharged droplets by means of said transducer; and
causing said droplets, upon formation, to pass through the charging field of a charging electrode, thereby inducing an electric charge on each droplet before contacting said surface;
whereby the charged droplets discharge their electric charge by earthing on contact with the surface of said eye.
3 Assignments
0 Petitions
Accused Products
Abstract
A method of administering to the eye a liquid ophthalmic formulation, comprising an ophthalmologically acceptable liquid and optionally containing an ophthalmologically-active substance, characterized in that the formulation has a viscosity in the range 10-3 to 1.0 Pa.s and a resistivity lower than 104 ohm.cm, and that a jet of the formulation is ejected towards the eye, from a spray nozzle situated adjacent to a piezoelectric or electromagnetic transducer, to form a stream of uniformly-sized, equally spaced, uncharged droplets, the stream of uncharged droplets is subsequently directed past a charging electrode to induce an electric charge on each droplet in the stream, and the charged droplets discharge their electric charge by earthing on contact with the eye; and spraying apparatus suitable for use in that method.
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Citations
12 Claims
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1. A method for administering a liquid ophthalmic formulation to the surface of the eye, said method comprising the steps of:
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providing a spray nozzle having a liquid outlet in proximity to but spaced from said surface, said nozzle being situated adjacent to a piezoelectric or electromagnetic transducer; providing to said nozzle said liquid ophthalmic formulation comprising an ophthalmologically-acceptable liquid having a viscosity in the range 10-3 to 1.0 Pa.s and a resistivity lower than 104 ohm.cm; ejecting a jet of said formulation from said spray nozzle towards said surface, forming a stream of uniformly-sized, equally spaced, uncharged droplets by means of said transducer; and causing said droplets, upon formation, to pass through the charging field of a charging electrode, thereby inducing an electric charge on each droplet before contacting said surface;
whereby the charged droplets discharge their electric charge by earthing on contact with the surface of said eye. - View Dependent Claims (2, 3, 4)
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5. Apparatus for treating an eye by administering a measured volume of a liquid ophthalmic formulation to the surface of said eye, comprising:
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at least one spray nozzle having a liquid outlet having an interior cross section adapted to retain therein a measured volume of a liquid formulation by surface tension; means to supply said measured volume of liquid formulation to said spray nozzle; means to eject said measured volume of liquid formulation from said spray nozzle outlet as a jet; a piezoelectric or electromagnetic transducer adapted to excite said jet of liquid formulation to form a stream of droplets of said liquid formulation; a charging electrode spaced co-axially in front of said spray nozzle outlet and adapted so that said droplets, upon formation, are charged by said electrode; and means to apply a voltage to said electrode;
said apparatus being adapted, when said nozzle outlet is in a spaced relationship with said surface, to direct said droplets toward said surface, and to permit said charged droplets to discharge their electric charge by earthing on contact with the surface of said eye. - View Dependent Claims (6, 7, 8, 9, 10, 11)
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12. Apparatus for treating an eye by administering a measured volume of a liquid ophthalmic formulation to the surface of said eye, said apparatus comprising:
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a body member, of a suitable size to be hand-held in use, having a tubular guide with one end thereof mounted on a first exterior wall of said body member, the other end of said guide being open and having a diameter approximating to the size of the eye surface to be treated; a narrow bore tube positioned in said body member and having an outlet end extending through said exterior wall substantially coaxial with and in open communication with said guide, said tube having an inlet end in open communication with a wider bore tubular section having a spring-loaded piston, located in and operable from a second exterior wall of said body member; an annular piezoelectric or electromagnetic transducer attached to said body member, and having a central orifice, coaxial with and in open communication with the outlet end of said tube and with said guide; a nozzle detachably attached to said body member within the central orifice of said transducer, coaxial with and in communication with said tube outlet, said nozzle being adapted to be detached from said body member in order to be charged with the formulation to be administered and then re-attached thereto; a voltage generator adapted to power said transducer through electrical connections via a frequency control unit, said generator and control unit being positioned within said body member; and an annular charging electrode located within the tubular guide, having a central opening coaxial with the central orifice of said transducer, said electrode being in a spaced relationship with said transducer and electrically insulated said body member, tubular nozzle, transducer and nozzle, and said electrode being adapted to receive a positive or negative electrical charge from said voltage generator with said charge having a pulse frequency controlled through said frequency control unit.
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Specification