Biocompatible surgical implant
First Claim
1. A surgical prosthesis for soft tissue reconstruction or augmentation in a mammal comprising a resorption-resistant semisolid fibrin coagulate consisting essentially of insoluble fibrin polymer strands stabilized against biodegradation and sealed in a biocompatible, resorption-resistant plastic shell, wherein the semisolid fibrin coagulate is produced from a fibrinogen solution consisting essentially of fibrinogen, thrombin, and factor XIII in amounts sufficient to substantially convert the fibrinogen to insoluble fibrin polymer.
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Abstract
The invention provides a biocompatible surgical implant particularly useful for breast or testicular reconstruction or augmentation comprising a stabilized fibrin semisolid, optionally sealed in a shaped shell. Preferred starting material for production of the implant is whole plasma from autologous or homologous donation, concentrated with respect to fibrinogen.
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Citations
23 Claims
- 1. A surgical prosthesis for soft tissue reconstruction or augmentation in a mammal comprising a resorption-resistant semisolid fibrin coagulate consisting essentially of insoluble fibrin polymer strands stabilized against biodegradation and sealed in a biocompatible, resorption-resistant plastic shell, wherein the semisolid fibrin coagulate is produced from a fibrinogen solution consisting essentially of fibrinogen, thrombin, and factor XIII in amounts sufficient to substantially convert the fibrinogen to insoluble fibrin polymer.
Specification