Anhydrous tooth whitening gel

• US 5,631,000 A
• Filed: 03/11/1996
• Issued: 05/20/1997
• Est. Priority Date: 03/11/1996
• Status: Expired due to Fees

• Current Assignee: Laclede Professional Products, Inc.
• Original Assignee: Laclede Professional Products, Inc.
• Inventors: Sababa, Veronica, Pellico, Michael A.
• Primary Examiner(s): Kulkosky, Peter F.
• Application Number:
  US08/599,364
• Time in Patent Office: 435 Days
• Field of Search: 424/50, 424/53, 424/54
• US Class Current: 424/53
• CPC Class Codes: A61K 2800/31 Anhydrous
• CPC Class Codes: A61K 2800/52 Stabilizers
• CPC Class Codes: A61K 2800/5422 nonionic
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/22 Peroxides; Oxygen; Ozone
• CPC Class Codes: A61K 8/345 containing more than one hydroxy group
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61K 8/73 Polysaccharides
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 8/8147 Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

An anhydrous dental bleaching gel composition is provided which has improved package stability, improved rheology and reduced sensitivity during use. An illustrative anhydrous dental bleaching gel composition embodying these features comprises propylene glycol, polyethylene glycol, glycerin in an amount not exceeding about 10 wt. %, neutralized carboxypolymethylene, hydroxypropylcellulose, and carbamide peroxide.

Claims

1. An anhydrous tooth whitening gel composition comprising carbamide peroxide dispersed in an anhydrous gelatinous carrier, said carrier comprising:

(a) a liquid polyol wherein glycerin, if present, is limited to an amount that does not exceed about 10 wt. % based on the total weight of the composition; and

(b) a thickener component containing neutralized carboxypolymethylene and cellulosic ether soluble in the liquid component,

said anhydrous tooth whitening gel composition having enhanced package stability, reduced tooth sensitivity, and improved thixotropic properties.

2. The composition of claim 1 wherein the liquid component includes propylene glycol in an amount from about 10 wt. % to about 55 wt. % based on the total weight of the composition and polyethylene glycol in an amount from about 10 wt. % to about 50 wt. % based on the total weight of the composition, said polyethylene glycol having a molecular wt. from about 400 to about 1500.

3. The composition of claim 1 wherein glycerin is present in an amount from about 3.0 wt. % to about 9.0 wt. %.

4. The thickener of claim 1 wherein the cellulosic ether is hydroxypropylcelluose in an amount from about 0.5 wt. % to about 10 wt. % based on the total weight of the composition and the concentration of carboxypolymethylene in the composition is from about 0.5 wt. % to about 3.0 wt. %.

5. The composition of claim 1 wherein the concentration of carbamide peroxide is from about 5.0 wt. % to about 25 wt. %.

6. An anhydrous tooth whitening gel composition comprising:

(a) propylene glycol in an amount from about 10 wt. % to about 55 wt. %,

(b) polyethylene glycol in an amount from about 10 wt. % to about 50 wt. %, and having a molecular weight from about 400 to about 1500,

(c) glycerin in an amount from about 0 wt. % to about 10 wt. %,

(d) carboxypolymethylene in an amount from about 0.5 wt. % to about 3.0 wt. %,

(e) hydroxypropylcellulose in an amount from about 0.5 wt. % to about 10 wt. %,

(f) neutralizing reagent in an amount to substantially neutralize carboxypolymethylene, and

(g) carbamide peroxide in an amount from about 5.0 wt. % to about 25 wt. %,

said anhydrous tooth whitening gel composition having enhanced package stability, reduced tooth sensitivity, and improved thixotropic properties.

7. The composition of claim 6 wherein propylene glycol is present in an amount from about 25 wt. % to about 45 wt. %.

8. The composition of claim 6 wherein polyethylene glycol is present in an amount from about 25 wt. % to about 45 wt. %.

9. The composition of claim 6 wherein glycerin is present in an amount from about 3.0 wt. % to about 9.0 wt. %.

10. The composition of claim 6 wherein carboxypolymethylene is present in an amount from about 1.5 wt. % to about 2.5 wt. %.

11. The composition of claim 6 wherein hydroxypropylcellulose is present in an amount from about 1.0 wt. % to about 3.0 wt. %.

12. The composition of claim 6 wherein carbamide peroxide is present in an amount from about 10 wt. % to about 20 wt. %.

13. A method for whitening teeth which comprises:

(1) extruding an anhydrous tooth whitening gel composition into the reservoir system of a tooth bleaching dental tray, said gel composition comprising;

(a) propylene glycol in an amount from about 10 wt. % to about 55 wt. %,

(b) polyethylene glycol in an amount from about 10 wt. % to about 50 wt. %, and having a molecular weight from about 400 to about 1500,

(c) glycerin in an amount from about 0 wt. % to about 10 wt. %,

(d) carboxypolymethylene in an amount from about 0.5 wt. % to about 3.0 wt. %,

(e) hydroxypropylcellulose in an amount from about 0.5 wt. % to about 10 wt. %,

(f) neutralizing reagent in an amount to substantially neutralize carboxypolymethylene, and

(g) carbamide peroxide in an amount from about 5.0 wt. % to about 25 wt. %;

(2) placing said dental tray in the oral cavity so as to bring the gel composition into contact with the teeth to be whitened;

(3) maintaining said gel composition in contact with said teeth for a plurality of hours per day; and

(4) repeating steps 1, 2 and 3 for multiple days to thereby whiten the teeth,

said anhydrous tooth whitening gel composition having enhanced package stability, reduced tooth sensitivity, and improved thixotropic properties.

14. The method of claim 13 wherein glycerin is present in the gel composition in an amount from about 3.0 wt. % to about 9.0 wt. %.

15. The method of claim 13 wherein carboxypolymethylene is present in the gel composition in an amount from about 1.5 wt. % to about 2.5 wt. %.

16. The method of claim 13 wherein hydroxypropylcellulose is present in the gel composition in an amount from about 1.0 wt. % to about 3.0 wt. %.

17. A method for preparing an anhydrous tooth whitening gel composition, which method comprises admixing:

(a) propylene glycol in an amount from about 10 wt. % to about 55 wt. %,

(b) polyethylene glycol in an amount from about 10 wt. % to about 50 wt. %,

(c) glycerin in an amount from about 0 wt. % to about 10 wt. %,

(d) carboxypolymethylene in an amount from about 0.5 wt. % to about 3.0 wt. %,

(e) hydroxypropylcellulose in an amount from about 0.5 wt. % to about 10 wt. %,

(f) neutralizing reagent in an amount to substantially neutralize carboxypolymethylene, and

(g) carbamide peroxide in an amount from about 5.0 wt. % to about 25 wt. %,

(h) wherein weight percent is based on the total weight of the gel composition,

said anhydrous tooth whitening gel composition having enhanced package stability, reduced tooth sensitivity, and improved thixotropic properties.

18. The method of claim 17 wherein the amount of glycerin is from about 3.0 wt. % to about 9.0 wt. %.

19. The method of claim 17 wherein the amount of carboxypolymethylene is from about 1.5 wt. % to about 2.5 wt. % and the amount of hydroxypropylcellulose is from about 1.0 wt. % to about 3.0 wt. %.

20. The method of claim 17 wherein said admixing is carried out under vacuum conditions.