Method for the quantitative determination of glycated proteins
First Claim
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1. A method for the determination of a glycated protein relative to non-glycated protein in an aqueous sample, comprising:
- reacting the sample with a proteolytic enzyme to form a peptide mixture comprising an amount of glycated peptides and an amount of non-glycated peptides,separating said glycated peptides and said non-glycated peptides in said peptide mixture, anddetermining said glycated protein relative to said non-glycated protein by measuring the amount of said glycated peptides and the amount of said non-glycated peptides and comparing the amount of said glycated peptides with the amount of said non-glycated peptides.
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Abstract
Method for the quantitative determination of glycated protein in particular haemoglobin and HbA1c, wherein the respective sample is firstly contacted with a proteolytic enzyme and subsequently a non-immunological chromatographic separation process is carried out.
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Citations
19 Claims
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1. A method for the determination of a glycated protein relative to non-glycated protein in an aqueous sample, comprising:
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reacting the sample with a proteolytic enzyme to form a peptide mixture comprising an amount of glycated peptides and an amount of non-glycated peptides, separating said glycated peptides and said non-glycated peptides in said peptide mixture, and determining said glycated protein relative to said non-glycated protein by measuring the amount of said glycated peptides and the amount of said non-glycated peptides and comparing the amount of said glycated peptides with the amount of said non-glycated peptides. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification