Process and solvate of 2-methyl-thieno-benzodiazepine
First Claim
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1. A crystalline mono methanol solvate form of a compound of the Formula I ##STR3##
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Abstract
The invention provides lower alcohol solvates of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) and a process for making such lower alcohol solyates of olanzapine. The invention provides a method for using such solyates of olanzapine to prepare substantially pure anhydrous Form I 2-methyl-thieno-benzodiazepine.
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Citations
10 Claims
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1. A crystalline mono methanol solvate form of a compound of the Formula I ##STR3##
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2. A crystalline mono ethanol solvate form of a compound of the Formula I ##STR4##
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3. A crystalline mono 1-propanol solvate form of a compound of the Formula I ##STR5##
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4. A process for preparing a lower alcohol solvate comprising preparing technical olanzapine which comprises contacting intermediate 1 ##STR6## with dimethylsulfoxide and N-methylpiperazine with heating at about 90°
- C. to about 130°
C.; andcrystallizing olanzapine from the reaction mixture with a solvent selected from the group consisting of lower alcohols to provide the corresponding lower alcohol solvate of olanzapine. - View Dependent Claims (5, 6, 7, 8, 9, 10)
- C. to about 130°
Specification