Two-pulse, lateral tissue illuminator

• US 5,632,739 A
• Filed: 10/13/1994
• Issued: 05/27/1997
• Est. Priority Date: 10/13/1994
• Status: Expired due to Fees

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Anderson, Richard R., Grocela, Joseph A.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): HARRIS, SONYA C
• Application Number:
  US08/323,295
• Time in Patent Office: 957 Days
• Field of Search: 606/2, 606/10, 606/11, 606/12, 606/13, 606/14, 606/15, 606/16, 606/17, 606/18
• US Class Current: 606/2
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 2017/00176 Two pulses, e.g. second pulse having an effect different from the first one
• CPC Class Codes: A61B 2017/22008 used or promoted
• CPC Class Codes: A61B 2018/2272 with reflective or refractive surfaces for deflecting the beam A61B2018/2261, A61B2018/2266 take precedence

Abstract

A two-pulse, lateral tissue illuminator in which a first pulse delivered by a first optical waveguide is used to irradiate a liquid-containing region to form a vapor bubble; a second pulse, delivered by a second optical waveguide, is then passed through the vapor bubble and used to incise a tissue of a patient. The illuminating device can be used to effectively deliver radiation to tissue positioned laterally relative to the axis of the delivery fibers, and allows a reduction in the attenuation of the radiation by the surrounding liquid.

Claims

1. A method of delivering a pulse of optical radiation through a liquid-containing region proximal to a tissue of a patient, and then to the tissue so as to irradiate portions thereof, the method comprising the steps of:

generating first and second optical pulses, wherein the first optical pulse is of sufficient intensity to form a vapor bubble in the liquid-containing region, and the second optical pulse is of sufficient energy, after passing through the vapor bubble, to irradiate portions of the tissue;

delivering the first optical pulse through a first optical waveguide and into the liquid-containing region so as to form the vapor bubble along a first pathway in the liquid-containing region;

allowing the vapor bubble to expand to displace some of the liquid in the liquid-containing region along the first pathway; and

delivering the second optical pulse (a) through a distal end of a second optical waveguide and along a second pathway substantially orthogonal to the first pathway;

(b) through a portion of the vapor bubble; and

(c) to the tissue of the patient, said delivery along the second pathway reducing attenuation of the second optical pulse by the liquid, thereby increasing the amount of radiation available for irradiating the tissue.

2. The method of claim 1, wherein said step of delivering the second pulse further includes, prior to step (b), the step of irradiating a partially reflective surface contained in a chamber enclosing a distal end of the second optical waveguide, the surface being irradiated at an angle so that the second pulse propagates out of the chamber along a pathway substantially orthogonal to the pathway of the first pulse.

3. The method of claim 2, wherein the surface is irradiated so that the second pathway along which the second optical pulse is delivered is oriented at an angle of between 70 and 110 degrees relative to the longitudinal axis of the second optical waveguide.

4. The method of claim 3, wherein the angle is about 90 degrees.

5. The method of claim 2, wherein a tissue sample positioned along the second pathway is irradiated during delivery of the second optical pulse.

6. The method of claim 5, wherein the tissue sample is the prostate gland, and the first and second optical waveguides are inserted into the urethra of the patient.

7. The method of claim 1, wherein the predetermined time period allows the vapor bubble to expand along portions of the second pathway.

8. The method of claim 7, wherein the predetermined time period allows the vapor bubble to expand to completely span the second pathway.

9. The method of claim 1, wherein said predetermined time period is between 100 and 1000 microseconds.

10. The method of claim 1, wherein during said generating a single light source is used to generate the first and second optical pulses.

11. The method of claim 10, wherein the first and second optical pulses are in the infrared spectral region.

12. The method of claim 1, wherein the first and second optical pulses have durations of between 100 and 1000 microseconds.

13. The method of claim 12, wherein the first optical pulse is strongly absorbed by the liquid-containing region, and the second optical pulse is strongly absorbed by the tissue.

14. The method of claim 13, wherein the first and second optical pulses are in the infrared spectral region.

15. The method of claim 13, wherein the first optical pulse is in the infrared spectral region, and the second optical pulse is in the visible spectral region.

16. The method of claim 1, wherein during said generating two separate light sources are used to generate the first and second optical pulses.