Adhesive compositions, wound dressings and methods

• US 5,633,010 A
• Filed: 06/06/1995
• Issued: 05/27/1997
• Est. Priority Date: 10/05/1992
• Status: Expired due to Term

• Current Assignee: The Boeing Co.
• Original Assignee: Minnesota Mining and Manufacturing Co (3M Company)
• Inventors: Chen, Yen-Lane
• Primary Examiner(s): Bawa, Raj
• Application Number:
  US08/469,023
• Time in Patent Office: 721 Days
• Field of Search: 424/445, 424/447, 424/448, 424/449, 424/443, 524/528
• US Class Current: 424/448
• CPC Class Codes: A61L 15/585 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: A61L 2400/14 Adhesives for ostomy devices
• CPC Class Codes: A61L 26/0052 Mixtures of macromolecular compounds
• CPC Class Codes: C08L 9/00 Compositions of homopolymers or copolymers of conjugated diene hydrocarbons
• CPC Class Codes: C09J 121/00 Adhesives based on unspecified rubbers

Abstract

Hydrocolloid adhesive compositions are disclosed comprising a hydrophobic unsaturated aliphatic homopolymer, a compatible tackifier, and at least one hydrocolloid absorbent. The compositions have enhanced resistance to breakdown by body fluids, adjustable absorbency, improved adhesive and cohesive properties, as well as a reduced tendency to leave an adhesive residue after application. Also disclosed are wound dressings, ostomy or prosthesis adhesives, methods of using wound dressings, and methods for forming the hydrocolloid adhesive compositions.

Claims

1. A pressure sensitive hydrocolloid adhesive composition consisting essentially of i) about 20-50 percent by weight of a hydrophobic, unsaturated, elastomeric homopolymer, ii) about 20-60 percent by weight of a tackifier selected from the group consisting of polyisobutylene, synthetic polyterpene tackifiers and combinations thereof and iii) about 5-60 percent by weight of a hydrocolloid absorbent selected from the group consisting of a natural hydrocolloid, a semi-synthetic hydrocolloid, a synthetic hydrocolloid, and combinations thereof, wherein the homopolymer is cross-linked by 5-200 kGy gamma radiation to provide the composition with a cross-linked matrix having a wet integrity value of at least about eighty percent, a shear hold value of at least 500 min/500 g and a dry cohesive strength which prevents adhesive composition breakage or delamination when a 1×

6 cm strip of the adhesive composition is slowly peeled off a polyester adhesive tape at a 90 degree angle and at a speed of 10 mm/minute.

2. An adhesive composition of claim 1, wherein the hydrophobic, unsaturated, elastomeric homopolymer has at least about 50 mole percent unsaturation.

3. An adhesive composition of claim 1, wherein the hydrophobic, unsaturated, elastomeric homopolymer has at least about 90 mole percent unsaturation.

4. An adhesive composition of claim 1, wherein the hydrophobic, unsaturated, elastomeric homopolymer is selected from the group consisting of a straight-chain unsaturated aliphatic homopolymer, a branched unsaturated aliphatic homopolymer, and combinations thereof.

5. An adhesive composition of claim 4, wherein the elastomeric homopolymer is selected from the group consisting of polyisoprene, polybutadiene, and combinations thereof.

6. An adhesive composition of claim 1, wherein the tackifier comprises a nonelastomeric synthetic polyterpene tackifier.

7. An adhesive composition of claim 1, wherein the hydrocolloid absorbent is selected from the group consisting of pectin, gelatin, a carboxymethylcellulose salt, a cross-linked carboxymethylcellulose salt, cross-linked polyacrylic acid, and combinations thereof.

8. An adhesive composition of claim 1 containing about 0.5 percent to 10 percent by weight of a plasticizer component.

9. An adhesive composition of claim 1, wherein the adhesive composition exhibits a wet integrity value of at least about ninety percent.

10. A wound dressing comprising the adhesive composition of claim 1 coated on a surface of a moisture vapor permeable backing.

11. A wound dressing of claim 10, wherein the backing further comprises a release coating coated on the surface of the backing opposite the surface coated with the adhesive composition.

12. A wound dressing of claim 10, wherein the backing is a transparent film of polyurethane or porous polyethylene.

13. A wound dressing of claim 10, wherein the backing extends beyond the periphery of the adhesive coating on all sides, and wherein at least a portion of the extended backing surface is coated with a second pressure sensitive adhesive.

14. A method of treating a wound comprising applying to the wound the composition of claim 1.

15. A method of forming a pressure sensitive adhesive composition comprising:

(a) compounding a mixture of i) about 20-50 percent by weight of a hydrophobic, unsaturated, elastomeric homopolymer, ii) about 20-60 percent by weight of a tackifier selected from the group consisting of polyisobutylene, synthetic polyterpene tackifiers and combinations thereof and iii) about 5-60 percent by weight of a hydrocolloid absorbent selected from the group consisting of a natural hydrocolloid, a semi-synthetic hydrocolloid, a synthetic hydrocolloid, and combinations thereof to form a hydrocolloid adhesive mass; and

(b) irradiating the hydrocolloid adhesive mass with a dose of radiation of from about 5 kGy to 200 kGy.

16. A method of forming an adhesive composition of claim 15, further comprising, adding a plasticizer to the mixture.

17. A method of forming an adhesive composition of claim 15, further comprising adhering the adhesive sheet to a least a portion of one major surface of a moisture vapor permeable backing.