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Progesterone replacement therapy

  • US 5,633,011 A
  • Filed: 08/04/1994
  • Issued: 05/27/1997
  • Est. Priority Date: 08/04/1994
  • Status: Expired due to Term
First Claim
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1. An article of manufacture for hormone replacement comprising a drug layer comprising 10 ng to 1200 mg of a progestin, 1 mg to 30 mg of a surfactant, 5 mg to 225 mg of an alkali carboxymethylcellulose possessing a 75,000 to 350,000 molecular weight, 0.05 mg to 20 mg of a disintegrant and 0.5 mg to 75 mg of an osmagent;

  • a displayment layer comprising 50 mg to 200 mg of an alkali carboxymethylcellulose of 500,000 to 1,000,000 molecular weight, 1 mg to 20 mg of a hydroxypropylmethylcellulose of 9,000 to 150,000 molecular weight, and 0.5 mg to 100 mg of an osmagent; and

    wherein the drug layer and the displacement layer are encased by hydroxypropylcellulose.

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