Method and apparatus for assessing cardiovascular performance

• US 5,634,467 A
• Filed: 11/01/1994
• Issued: 06/03/1997
• Est. Priority Date: 11/08/1993
• Status: Expired due to Fees

• Current Assignee: Robin Medical Technologies Limited
• Original Assignee: Robin Medical Technologies Limited
• Inventors: Nevo, Erez
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): HUANG, STEPHEN D
• Application Number:
  US08/332,946
• Time in Patent Office: 945 Days
• Field of Search: 128/670, 128/672, 128/677, 128/680, 128/681, 128/683, 128/687, 128/688
• US Class Current: 600/490
• CPC Class Codes: A61B 5/0225 the pressure being controlled by electric signals, e.g. derived from Korotkoff sounds
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence

Abstract

A method of assessing the cardiovascular performance of a subject, by: applying periodically, in synchronism with every n^th heart cardiac cycle wherein "n" is at least two, external pressure pulsations on a peripheral organ of the subject sufficient to alter ventricular loading; acquiring data representative of the ventricular pressure, and data representative of the ventricular volume, of the subject'"'"'s heart over a plurality of heart cardiac cycles; and utilizing such data for assessing the cardiovascular performance of the subject. Ventricular loading may be altered by impeding ventricular ejection (changing afterload), and/or by altering venous return to the heart (changing preload).

Claims

1. A method of assessing the cardiovascular performance of a subject, comprising:

applying periodically, for at least one complete heart cardiac cycle and in synchronism with every n^th heart cardiac cycle wherein "n" is at least two, external pressure pulsations, by a pressure applicator applied externally of the subject'"'"'s body, on a peripheral organ of the subject sufficient to alter ventricular loading;

acquiring data representative of the ventricular pressure, and data representative of the ventricular volume, of the subject'"'"'s heart over a plurality of heart cardiac cycles;

and utilizing said data for assessing the cardiovascular performance of the subject.

2. The method according to claim 1, wherein said external pressure pulsations are applied during every other heart cardiac cycle, such that n=2.

3. The method according to claim 1, wherein said external pressure pulsations are applied during a plurality (N₁) cardiac cycles, and are released during a plurality (N₂) cardiac cycles, such that n=N₁ +N₂.

4. The method according to claim 1, wherein said acquired data is utilized for assessing the cardiovascular performance of the subject by:

determining the end systolic pressure volume relation (ESPVR) of the subject'"'"'s heart during (a) the heart cardiac cycles in which said external pressure pulsations are applied, and (b) the heart cardiac cycles in which the external pressure pulsations are not applied;

and determining the slope of the ESPVR during the heart cardiac cycles (a) and (b) to thereby provide an approximation of the ventricular elastance of the subject'"'"'s heart.

5. The method according to claim 4, wherein, in order to determine the ESPVR, the acquired data includes a measurement (Va) of the volume of the heart left ventricle as a function of time during said heart cardiac cycles (a), and a corresponding measurement (Vb) during the heart cardiac cycles (b);

the acquired data also includes measurements of the arterial blood pressure, being used to construct at least a portion (Pa) of the arterial pressure wave during the cardiac cycles (a), and a corresponding portion (Pb) of the left ventricular pressure wave during the cardiac cycles (b);

determining from said portions (Pa) and (Pb) the relations P(V)a and P(V)b of ventricular pressure with respect to ventricular volume during the heart cardiac cycles (a) and (b), respectively;

and determining from said relations P(V)a and P(V)b the ESPVR during the cardiac cycles (a) and (b), respectively.

6. The method according to claim 5, wherein measurements (Va) and (Vb) are made by measuring the average aortic flow during said cardiac cycles (a) and (b);

and integrating said average aortic flows over said plurality of cardiac cycles.

7. The method according to claim 1, wherein said external pressure pulsations are pneumatically applied.

8. The method according to claim 1, wherein said external pressure pulsations are applied to a limb and/or abdomen of the subject.

9. Apparatus for assessing the cardiovascular performance of a subject, comprising:

a pressure applicator and a control therefor for applying periodically, for at least one complete heart cardiac cycle and in synchronism with every n^th heart cardiac cycle wherein "n" is at least two, external pressure pulsations on a peripheral organ of the subject sufficient to alter ventricular loading;

sensors for sensing parameters of the subject varying with the left-ventricular blood pressure and the left-ventricular volume of the subject'"'"'s heart, and for producing outputs corresponding to said sensed parameters;

and a data processor for processing the outputs of said sensors and for producing data representative of the left-ventricular blood pressure and the left-ventricular volume of the subject'"'"'s heart over a plurality of heart cardiac cycles and useful in assessing the cardiovascular performance of the subject.

10. The apparatus according to claim 9, wherein said data processor processes the outputs of said sensors:

to determine the end systolic pressure volume relation (ESPVR) of the subject'"'"'s heart during (a) the heart cardiac cycles in which said external pressure pulsations are applied, and (b) the cardiac cycles during which the external pressure pulsations are not applied; and

also to determine the slope of the ESPVR during the heart cardiac cycles (a) and (b), to thereby provide an approximation of the ventricular elastance of the subject'"'"'s heart.

11. The apparatus according to claim 10, wherein said data processor:

produces a measurement (Va) of the volume of the heart left ventricle as a function of time during said cardiac cycles (a), and a corresponding measurement (Vb) during the cardiac cycles (b);

constructs from said left-ventricular blood pressure data at least a portion (Pa) of the pressure wave during the cardiac cycles (a) and a corresponding portion (Pb) of the pressure wave during the cardiac cycles (b);

determines from said measurements Pa, Va and Pb, Vb the relations P(V)a and P(V)b of left-ventricular blood pressure with respect to ventricular volume during the heart cardiac cycles (a) and (b), respectively; and

determines from said relations P(V)a and P(V)b, the ESPVR during the heart cardiac cycles (a) and (b), respectively.

12. The apparatus according to claim 11, wherein said data processor produces measurements (Va) and (Vb) by measuring the average aortic flow during said heart cardiac cycles (a) and (b), and by integrating the average aortic flows over the plurality of heart cardiac cycles.

13. The apparatus according to claim 9, wherein said pressure applicator is a pneumatic device.

14. Apparatus for assessing the cardiovascular performance of a subject, comprising:

a pressure applicator and a control therefor for applying periodically, for at least one complete heart cardiac cycle and in synchronism with every n^th heart cardiac cycle wherein "n" is at least two, external pressure pulsations on a peripheral organ of the subject sufficient to alter ventricular loading;

a pressure sensor for sensing the aortic pressure of the subject;

a flow rate sensor for sensing the aortic flow rate of the subject;

and a data processor for processing outputs from the pressure sensor and flow rate sensor, and for producing data representative of the ventricular pressure, and data representative of the ventricular volume, of the subject'"'"'s heart over a plurality of heart cardiac cycles, which data useful in assessing the cardiovascular performance of the subject.

15. The apparatus according to claim 14, wherein said data processor processes the outputs of said sensors:

to determine the end systolic pressure volume relation (ESPVR) of the subject'"'"'s heart during (a) the cardiac cycles in which said external pressure pulsations are applied, and (b) the cardiac cycles during which the external pressure pulsations are not applied;

and also to determine the slope of the ESPVR during the heart cardiac cycles (a) and (b), to thereby provide an approximation of the ventricular elastance of the subject'"'"'s heart.

16. The apparatus according to claim 15, wherein said data processor:

produces a measurement (Va) of the volume of the heart left ventricle as a function of time during said cardiac cycles (a), and a corresponding measurement (Vb) during the cardiac cycles (b);

constructs from said left-ventricular blood pressure data at least a portion (Pa) of the pressure wave during the cardiac cycles (a) and a corresponding portion (Pb) of the pressure wave during the cardiac cycles (b);

determines from said measurements Pa, Va and Pb, Vb the relations P(V)a and P(V)b of ventricular pressure with respect to ventricular volume during the heart cardiac cycles (a) and (b), respectively;

and determines from said relations P(V)a and P(V)b, the ESPVR during the heart cardiac cycles (a) and (b), respectively.

17. The apparatus according to claim 16, wherein said data processor produces measurements (Va) and (Vb) by measuring the average aortic flow during said heart cardiac cycles (a) and (b), and by integrating the average aortic flows over the plurality of heart cardiac cycles.

18. The apparatus according to claim 14, wherein said pressure applicator is a pneumatic device.