Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof

• US 5,635,187 A
• Filed: 06/06/1995
• Issued: 06/03/1997
• Est. Priority Date: 11/30/1993
• Status: Expired due to Term

• Current Assignee: Sky High, LLC
• Original Assignee: LXR Biotechnology, Inc.
• Inventors: Bradley, John D., Barr, Philip J., Bathurst, Ian C., Tomei, L. David
• Primary Examiner(s): Rollins, John W.
• Application Number:
  US08/467,035
• Time in Patent Office: 728 Days
• Field of Search: 424/195.1, 435/283
• US Class Current: 424/757
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 35/20 Milk; Whey; Colostrum
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 8/9794 Liliopsida [monocotyledons]
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 31/18 for HIV
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 39/00 General protective or antinoxious agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The present invention is directed to methods of obtaining plant-derived delipidated extracts that inhibit apoptosis, the extracts obtained, compositions containing said extracts and methods of using said compositions. FIG. 11 is a bar graph which illustrates a lower incidence of diarrhea in rats treated with methotrexate and fed a diet of compositions of the claimed invention as compared to controls.

Claims

1. A method of increasing organ preservation for subsequent transplantation comprising adding

at least one phytogenic apoptosis inhibitor in an amount effective to maintain the organ prior to transplantation, to the solution in which the organ is stored.

2. A composition for maintaining and preserving organs prior to transplantation comprising an organ transplantation solution and at least one phytogenic apoptosis inhibitor in an amount effective to maintain the organ prior to transplantation.