Compounds having phosphorodithioate linkages of high chiral purity
First Claim
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1. An oligonucleotide represented by SEQ ID NO:
- 1 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
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Abstract
Sequence-specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence-specific phosphorothioate oligonucleotides having substantially chirally pure intersugar linkages are prepared by enzymatic or chemical synthesis. Sequence-specific phosphorodithioate oligonucleotides are also provided. Such sequence-specific phosphorodithioate oligonucleotides are prepared by chemical synthesis. They are especially well suited as diagnostics, therapeutics and research reagents.
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Citations
8 Claims
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1. An oligonucleotide represented by SEQ ID NO:
- 1 wherein at least 75% of the nucleoside units are joined together by Sp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (3, 6)
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2. An oligonucleotide represented by SEQ ID NO:
- 1 wherein at least 75% of the nucleoside units are joined together by Rp phosphorothioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (4, 7)
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5. An oligonucleotide represented by SEQ ID NO:
- 1 wherein all of the nucleoside units are joined together by phosphorodithioate 3'"'"' to 5'"'"' linkages.
- View Dependent Claims (8)
Specification