Ultrasound-enhanced sampling of materials through the skin
First Claim
1. A non-invasive method for sampling physiologic material present beneath the body surface of an individual, comprising applying ultrasound having a frequency of above 10 MHz to a selected intact area of the individual'"'"'s body surface, wherein said ultrasound is applied at an intensity and for a time period effective to enable movement of a diagnostic quantity of physiologic material through the selected intact area to the surface of said intact area and collecting the physiologic material into a collection chamber.
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Accused Products
Abstract
A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultra sound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.
157 Citations
19 Claims
- 1. A non-invasive method for sampling physiologic material present beneath the body surface of an individual, comprising applying ultrasound having a frequency of above 10 MHz to a selected intact area of the individual'"'"'s body surface, wherein said ultrasound is applied at an intensity and for a time period effective to enable movement of a diagnostic quantity of physiologic material through the selected intact area to the surface of said intact area and collecting the physiologic material into a collection chamber.
Specification