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Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems

  • US 5,637,469 A
  • Filed: 11/30/1994
  • Issued: 06/10/1997
  • Est. Priority Date: 05/01/1992
  • Status: Expired due to Term
First Claim
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1. A device for detecting the presence of an analyte in a fluid sample, the device comprising:

  • a solid substrate microfabricated to define;

    a sample inlet port, said port being dimensioned for connection to a pump means; and

    a mesoscale flow system comprising;

    a sample flow channel extending from said inlet port; and

    an analyte binding region in fluid communication with said flow channel comprising a binding moiety immobilized on a surface in said analyte binding region, wherein said binding moiety specifically binds to analyte in said fluid sample, at least one of said sample flow channel or said analyte binding region having mesoscale cross-sectional dimensions; and

    a binding means associated with said analyte binding region or in fluid communication with said analyte binding region for detecting binding of said analyte to said binding moiety.

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