Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
First Claim
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1. Pharmaceutical composition in unit dosage form useful for dismutating superoxide comprising (a) a therapeutically or prophylactically effective amount of a complex represented by the formula:
- ##STR8## wherein at least one of R and R'"'"', R1 and R'"'"'1, R2 and R'"'"'2, R3 and R'"'"'3, R4 and R'"'"'4, R5 and R'"'"'5, R6 and R'"'"'6, R7 and R'"'"'7, R8 and R'"'"'8, and R9 and R'"'"'9 together with the carbon atom to which they are attached independently form a saturated, partially saturated or unsaturated ring structure having 3 to 20 carbon atoms;
or at least one of R, R'"'"', R1, R'"'"'1, R2, R'"'"'2, R3, R'"'"'3, R4, R'"'"'4, R5, R'"'"'5,R6, R'"'"'6, R7, R'"'"'7, R8, R'"'"'8, R9, and R'"'"'9, together with a different one of R, R'"'"', R1, R'"'"'1, R2, R'"'"'2, R3, R'"'"'3, R4, R'"'"'4, R5, R'"'"'5, R6, R'"'"'6, R7, R'"'"'7, R8, R'"'"'8, R9, and R'"'"'9 which is attached to a different carbon atom in the macrocyclic ligand may be bound to form a strap represented by the formula ##STR9## wherein w, x, y and z independently are integers from 0 to 10, and M, L and J are independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heteroaryl, alkaryl, alkheteroaryl, aza, amide, ammonium, thia, sulfonyl, sulfinyl, sulfonamide, phosphonyl, phosphinyl, phosphino, phosphonium, keto, ester, carbamate, urea, thiocarbonyl, borates, boranes, boraza, silyl, siloxy, silaza and combinations thereof;
or combinations thereof; and
the remaining "R" groups are hydrogen or, optionally, R, R'"'"', R1, R'"'"'1, R2, R'"'"'2, R3, R'"'"'3, R4, R'"'"'4, R5, R'"'"'5, R6, R'"'"'6, R7, R'"'"'7, R8, R'"'"'8, R9, and R'"'"'9 independently are selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylcycloalkyl, cycloalkenylalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkylcycloalkenyl, alkenylcycloalkenyl, heterocyclic, aryl and aralkyl radicals and radicals attached to the α
-carbon of α
-amino acids;
or R1 R8 or R'"'"'8, and R9 or R'"'"'9 and R or R'"'"' together with the carbon atoms to which they are attached independently form a saturated, partially saturated or unsaturated cyclic having 3 to 20 carbon atoms;
or R or R'"'"' and R1 or R'"'"'1, R2 or R'"'"'2 and R3 or R'"'"'3, R4 or R'"'"'4 and R5 or R'"'"'5, R6 or R'"'"'6 and R7 or R'"'"'7, and R8 or R'"'"'8 and R9 or R'"'"'9 together with the carbon atoms to which they are attached independently form a nitrogen containing heterocycle having 2 to 20 carbon atoms provided that when the nitrogen containing heterocycle is an aromatic heterocycle which does not contain a hydrogen attached to the nitrogen, the hydrogen attached to the nitrogen in said formula, which nitrogen is also in the macrocycle and the R groups attached to the same carbon atoms of the macrocycle are absent; and
combinations thereof;
wherein X, Y and Z are ligands independently selected from the group consisting of halide, oxo, aquo, hydroxo, alcohol, phenol, dioxygen, peroxo, hydroperoxo, alkylperoxo, arylperoxo, ammonia, alkylamino, arylamino, heterocycloalkyl amino, heterocycloaryl amino, amine oxides, hydrazine, alkyl hydrazine, aryl hydrazine, nitric oxide, cyanide, cyanate, thiocyanate, isocyanate, isothiocyanate, alkyl nitrile, aryl nitrile, alkyl isonitrile, aryl isonitrile, nitrate, nitrite, azido, alkyl sulfonic acid, aryl sulfonic acid, alkyl sulfoxide, aryl sulfoxide, alkyl aryl sulfoxide, alkyl sulfenic acid, aryl sulfenic acid, alkyl sulfinic acid, aryl sulfinic acid, alkyl thiol carboxylic acid, aryl thiol carboxylic acid, alkyl thiol thiocarboxylic acid, aryl thiol thiocarboxylic acid, alkyl carboxylic acid, aryl carboxylic acid, urea, alkyl urea, aryl urea, alkyl aryl urea, thiourea, alkyl thiourea, aryl thiourea,alkyl aryl thiourea, sulfate, sulfite, bisulfate, bisulfite, thiosulfate, thiosulfite, hydrosulfite, alkyl phosphine, aryl phosphine, alkyl phosphine oxide, aryl phosphine oxide, alkyl aryl phosphine oxide, alkyl phosphine sulfide, aryl phosphine sulfide, alkyl aryl phosphine sulfide, alkyl phosphonic acid, aryl phosphortic acid, alkyl phosphinic acid, aryl phosphinic acid, alkyl phosphinous acid, aryl phosphinous acid, phosphate, thiophosphate, phosphite, pyrophosphite, triphosphate, hydrogen phosphate, dihydrogen phosphate, alkyl guanidino, aryl guanidino, alkyl aryl guanidino, alkyl carbamate, aryl carbamate, alkyl aryl carbamate, alkyl thiocarbamate, aryl thiocarbamate, alkylaryl thiocarbamate, alkyl dithiocarbamate, aryl dithiocarbamate, alkylaryl dithiocarbamate, bicarbonate, carbonate, perchlorate, chlorate, chlorite, hypochlorite, perbromate, bromate, bromite, hypobromite, tetrahalomanganate, tetrafluoroborate, hexafluoroantimonate, hypophosphite, iodate, periodate, metaborate, tetraaryl borate, tetra alkyl borate, hypophosphite, iodate, periodate, metaborate, tetraaryl borate, tetra alkyl borate, tartrate, salicylate, succinate, citrate, ascorbate, saccharinate, amino acid, hydroxamic acid, thiotosylate, and anions of ion exchange resins, or the corresponding anions thereof, or X, Y and Z are independently attached to one or more of the "R" groups and n is an integer from 0 to 3; and
(b) a nontoxic, pharmaceutically acceptable carrier, adjuvant or vehicle.
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Abstract
The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula: ##STR1## wherein R, R'"'"', R1, R'"'"'1, R2, R'"'"'2, R3, R'"'"'3, R4, R'"'"'4, R5, R'"'"'5, R6, R'"'"'6, R7, R'"'"'7, R8, R'"'"'8, R9, and R'"'"'9 and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury.
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Citations
3 Claims
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1. Pharmaceutical composition in unit dosage form useful for dismutating superoxide comprising (a) a therapeutically or prophylactically effective amount of a complex represented by the formula:
- ##STR8## wherein at least one of R and R'"'"', R1 and R'"'"'1, R2 and R'"'"'2, R3 and R'"'"'3, R4 and R'"'"'4, R5 and R'"'"'5, R6 and R'"'"'6, R7 and R'"'"'7, R8 and R'"'"'8, and R9 and R'"'"'9 together with the carbon atom to which they are attached independently form a saturated, partially saturated or unsaturated ring structure having 3 to 20 carbon atoms;
or at least one of R, R'"'"', R1, R'"'"'1, R2, R'"'"'2, R3, R'"'"'3, R4, R'"'"'4, R5, R'"'"'5,R6, R'"'"'6, R7, R'"'"'7, R8, R'"'"'8, R9, and R'"'"'9, together with a different one of R, R'"'"', R1, R'"'"'1, R2, R'"'"'2, R3, R'"'"'3, R4, R'"'"'4, R5, R'"'"'5, R6, R'"'"'6, R7, R'"'"'7, R8, R'"'"'8, R9, and R'"'"'9 which is attached to a different carbon atom in the macrocyclic ligand may be bound to form a strap represented by the formula ##STR9## wherein w, x, y and z independently are integers from 0 to 10, and M, L and J are independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heteroaryl, alkaryl, alkheteroaryl, aza, amide, ammonium, thia, sulfonyl, sulfinyl, sulfonamide, phosphonyl, phosphinyl, phosphino, phosphonium, keto, ester, carbamate, urea, thiocarbonyl, borates, boranes, boraza, silyl, siloxy, silaza and combinations thereof;
or combinations thereof; and
the remaining "R" groups are hydrogen or, optionally, R, R'"'"', R1, R'"'"'1, R2, R'"'"'2, R3, R'"'"'3, R4, R'"'"'4, R5, R'"'"'5, R6, R'"'"'6, R7, R'"'"'7, R8, R'"'"'8, R9, and R'"'"'9 independently are selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylcycloalkyl, cycloalkenylalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkylcycloalkenyl, alkenylcycloalkenyl, heterocyclic, aryl and aralkyl radicals and radicals attached to the α
-carbon of α
-amino acids;
or R1 R8 or R'"'"'8, and R9 or R'"'"'9 and R or R'"'"' together with the carbon atoms to which they are attached independently form a saturated, partially saturated or unsaturated cyclic having 3 to 20 carbon atoms;
or R or R'"'"' and R1 or R'"'"'1, R2 or R'"'"'2 and R3 or R'"'"'3, R4 or R'"'"'4 and R5 or R'"'"'5, R6 or R'"'"'6 and R7 or R'"'"'7, and R8 or R'"'"'8 and R9 or R'"'"'9 together with the carbon atoms to which they are attached independently form a nitrogen containing heterocycle having 2 to 20 carbon atoms provided that when the nitrogen containing heterocycle is an aromatic heterocycle which does not contain a hydrogen attached to the nitrogen, the hydrogen attached to the nitrogen in said formula, which nitrogen is also in the macrocycle and the R groups attached to the same carbon atoms of the macrocycle are absent; and
combinations thereof;
wherein X, Y and Z are ligands independently selected from the group consisting of halide, oxo, aquo, hydroxo, alcohol, phenol, dioxygen, peroxo, hydroperoxo, alkylperoxo, arylperoxo, ammonia, alkylamino, arylamino, heterocycloalkyl amino, heterocycloaryl amino, amine oxides, hydrazine, alkyl hydrazine, aryl hydrazine, nitric oxide, cyanide, cyanate, thiocyanate, isocyanate, isothiocyanate, alkyl nitrile, aryl nitrile, alkyl isonitrile, aryl isonitrile, nitrate, nitrite, azido, alkyl sulfonic acid, aryl sulfonic acid, alkyl sulfoxide, aryl sulfoxide, alkyl aryl sulfoxide, alkyl sulfenic acid, aryl sulfenic acid, alkyl sulfinic acid, aryl sulfinic acid, alkyl thiol carboxylic acid, aryl thiol carboxylic acid, alkyl thiol thiocarboxylic acid, aryl thiol thiocarboxylic acid, alkyl carboxylic acid, aryl carboxylic acid, urea, alkyl urea, aryl urea, alkyl aryl urea, thiourea, alkyl thiourea, aryl thiourea,alkyl aryl thiourea, sulfate, sulfite, bisulfate, bisulfite, thiosulfate, thiosulfite, hydrosulfite, alkyl phosphine, aryl phosphine, alkyl phosphine oxide, aryl phosphine oxide, alkyl aryl phosphine oxide, alkyl phosphine sulfide, aryl phosphine sulfide, alkyl aryl phosphine sulfide, alkyl phosphonic acid, aryl phosphortic acid, alkyl phosphinic acid, aryl phosphinic acid, alkyl phosphinous acid, aryl phosphinous acid, phosphate, thiophosphate, phosphite, pyrophosphite, triphosphate, hydrogen phosphate, dihydrogen phosphate, alkyl guanidino, aryl guanidino, alkyl aryl guanidino, alkyl carbamate, aryl carbamate, alkyl aryl carbamate, alkyl thiocarbamate, aryl thiocarbamate, alkylaryl thiocarbamate, alkyl dithiocarbamate, aryl dithiocarbamate, alkylaryl dithiocarbamate, bicarbonate, carbonate, perchlorate, chlorate, chlorite, hypochlorite, perbromate, bromate, bromite, hypobromite, tetrahalomanganate, tetrafluoroborate, hexafluoroantimonate, hypophosphite, iodate, periodate, metaborate, tetraaryl borate, tetra alkyl borate, hypophosphite, iodate, periodate, metaborate, tetraaryl borate, tetra alkyl borate, tartrate, salicylate, succinate, citrate, ascorbate, saccharinate, amino acid, hydroxamic acid, thiotosylate, and anions of ion exchange resins, or the corresponding anions thereof, or X, Y and Z are independently attached to one or more of the "R" groups and n is an integer from 0 to 3; and
(b) a nontoxic, pharmaceutically acceptable carrier, adjuvant or vehicle.
- ##STR8## wherein at least one of R and R'"'"', R1 and R'"'"'1, R2 and R'"'"'2, R3 and R'"'"'3, R4 and R'"'"'4, R5 and R'"'"'5, R6 and R'"'"'6, R7 and R'"'"'7, R8 and R'"'"'8, and R9 and R'"'"'9 together with the carbon atom to which they are attached independently form a saturated, partially saturated or unsaturated ring structure having 3 to 20 carbon atoms;
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2. A compound which is a complex represented by the formula:
- ##STR10## wherein at least one of R and R'"'"', R1 and R'"'"'1, R2 and R'"'"'2, R3 and R'"'"'3, R4 and R'"'"'4, R5 and R'"'"'5, R6 and R'"'"'6, R7 and R'"'"'7, R8 and R'"'"'8, and R9 and R'"'"'9, together with the carbon atoms to which they are attached independently form a saturated, partially saturated or unsaturated ring structure having 3 to 20 carbon atoms;
or at least one of R, R'"'"', R1, R'"'"'1, R2, R'"'"'2, R3, R'"'"'3, R4, R'"'"'4, R5, R'"'"'5, R6, R'"'"'6, R7, R'"'"'7, R8, R'"'"'8, R9, and R'"'"'9 together with a different one of R, R'"'"', R1, R'"'"'1, R2, R'"'"'2, R3, R'"'"'3, R4, R'"'"'4, R5, R'"'"'5, R6, R'"'"'6, R7, R'"'"'7, R8, R'"'"'8, R9, and R'"'"'9 which is attached to a different carbon atom in the macrocyclic ligand may be bound to form a strap represented by the formula ##STR11## wherein w, x, y and z independently are integers from 0 to 10, and M, L and J are independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, cycloalkyl, heteroaryl, alkaryl, alkheteroaryl, aza, amide, ammonium, thia, sulfonyl, sulfinyl, sulfonarnide, phosphonyl, phosphinyl, phosphino, phosphonium, keto, ester, carbamate, urea, thiocarbonyl, borates, boranes, boraza, silyl, siloxy, silaza and combinations thereof;
or combinations thereof; and
the remaining "R" groups are hydrogen or, optionally, R, R'"'"', R1, R'"'"'1, R2, R'"'"'2,R3, R'"'"'3, R4, R'"'"'4, R5, R'"'"'5, R6, R'"'"'6, R7, R'"'"'7, R8, R'"'"'8, R9, and R'"'"'9 independently are selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkylcycloalkyl, cycloalkenylalkyl, alkylcycloalkyl, alkenylcycloalkyl, alkylcycloalkenyl, alkenylcycloalkenyl, heterocyclic, aryl and aralkyl radicals and radicals attached to the α
-carbon of α
-amino acids;
or R1 or R'"'"'1 and R2 or R'"'"'2, R3 or R'"'"'3 and R4 or R'"'"'4, R5 or R'"'"'5 and R6 or R'"'"'6 R7 or R'"'"'7, and R8 or R'"'"'8, and R9 or R'"'"'9 and R or R'"'"' together with the carbon atoms to which they are attached independently form a saturated, partially saturated or unsaturated cyclic having 3 to 20 carbon atoms;
or R or R'"'"' and R1 or R'"'"'1, R2 or R'"'"'2 and R3 or R'"'"'3, R4 or R'"'"'4 and R5 or R'"'"'5, R6 or R'"'"'6 and R7 or R'"'"'7, and R8 or R'"'"'8 and R9 or R'"'"'9 together with the carbon atoms to which they are attached independently form a nitrogen containing heterocycle having 2 to 20 carbon atoms provided that when the nitrogen containing heterocycle is an aromatic heterocycle which does not contain a hydrogen attached to the nitrogen, the hydrogen attached to the nitrogen in said formula, which nitrogen is also in the macrocycle and the R groups attached to the same carbon atoms of the macrocycle are absent; and
combinations thereof;
wherein X, Y and Z are ligands independently selected from the group consisting of halide, oxo, aquo, hydroxo, alcohol, phenol, dioxygen, peroxo, hydroperoxo, alkylperoxo, arylperoxo, ammonia, alkylamino, arylamino, heterocycloalkyl amino, heterocycloaryl amino, amine oxides, hydrazine, alkyl hydrazine, aryl hydrazine, nitric oxide, cyanide, cyanate, thiocyanate, isocyanate, isothiocyanate, alkyl nitrile, aryl nitrile, alkyl isonitrile, aryl isonitrile, nitrate, nitrite, azido, alkyl sulfonic acid, aryl sulfonic acid, alkyl sulfoxide, aryl sulfoxide, alkyl aryl sulfoxide, alkyl sulfenic acid, aryl sulfenic acid, alkyl sulfinic acid, aryl sulfinic acid, alkyl thiol carboxylic acid, aryl thiol carboxylic acid, alkyl thiol thiocarboxylic acid, aryl thiol thiocarboxylic acid, alkyl carboxylic acid, aryl carboxylic acid, urea, alkyl urea, aryl urea, alkyl aryl urea, thiourea, alkyl thiourea, aryl thiourea,alkyl aryl thiourea, sulfate, sulfite, bisulfate, bisulfite, thiosulfate, thiosulfite, hydrosulfite, alkyl phosphine, aryl phosphine, alkyl phosphine oxide, aryl phosphine oxide, alkyl aryl phosphine oxide, alkyl phosphine sulfide, aryl phosphine sulfide, alkyl aryl phosphine sulfide, alkyl phosphonic acid, aryl phosphonic acid, alkyl phosphinic acid, aryl phosphinic acid, alkyl phosphinous acid, aryl phosphinous acid, phosphate, thiophosphate, phosphite, pyrophosphite, triphosphate, hydrogen phosphate, dihydrogen phosphate, alkyl guanidino, aryl guanidino, alkyl aryl guanidino, alkyl carbamate, aryl carbamate, alkyl aryl carbamate, alkyl thiocarbamate, aryl thiocarbamate, alkylaryl thiocarbamate, alkyl dithiocarbamate, aryl dithiocarbamate, alkylaryl dithiocarbamate, bicarbonate, carbonate, perchlorate, chlorate, chlorite, hypochlorite, perbromate, bromate, bromite, hypobromite, tetrahalomanganate, tetrafluoroborate, hexafluoroantimonate, hypophosphite, iodate, periodate, metaborate, tetraaryl borate, tetra alkyl borate, tartrate, salicylate, succinate, citrate, ascorbate, saccharinate, amino acid, hydroxamic add, thiotosylate, and anions of ion exchange resins, or the corresponding anions thereof, or X, Y and Z are independently attached to one or more of the "R" groups and n is an integer from 0 to 3. - View Dependent Claims (3)
- ##STR10## wherein at least one of R and R'"'"', R1 and R'"'"'1, R2 and R'"'"'2, R3 and R'"'"'3, R4 and R'"'"'4, R5 and R'"'"'5, R6 and R'"'"'6, R7 and R'"'"'7, R8 and R'"'"'8, and R9 and R'"'"'9, together with the carbon atoms to which they are attached independently form a saturated, partially saturated or unsaturated ring structure having 3 to 20 carbon atoms;
Specification
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Current AssigneePharmacia Corporation (Pfizer Inc.)
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Original AssigneeMonsanto Company (Bayer AG)
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InventorsModak, Anil S., Neuman, William L., Weiss, Randy H., Riley, Dennis P., Lennon, Patrick J., Aston, Karl W.
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Primary Examiner(s)Shah, Mukund J.
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Assistant Examiner(s)Sripada, Pavanaram K.
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Application NumberUS08/442,454Time in Patent Office756 DaysField of Search540/474, 540/472, 514/183, 514/186, 514/184US Class Current514/186CPC Class CodesC07D 259/00 Heterocyclic compounds cont...C07F 13/005 Compounds without a metal-c...Y10S 977/915 Therapeutic or pharmaceutic...
