Solvate of olanzapine

• US 5,637,584 A
• Filed: 03/24/1995
• Issued: 06/10/1997
• Est. Priority Date: 03/24/1995
• Status: Expired due to Term

• Current Assignee: Eli Lilly and Company, Lilly Industries Limited
• Original Assignee: Eli Lilly and Company, Lilly Industries Limited
• Inventors: Larsen, Samuel D.
• Primary Examiner(s): McKane, Joseph
• Assistant Examiner(s): MYERS, RICHARD
• Application Number:
  US08/410,263
• Time in Patent Office: 809 Days
• Field of Search: 540/557, 514/220
• US Class Current: 514/220
• CPC Class Codes: C07D 495/04 Ortho-condensed systems

Abstract

The invention provides a methylene chloride solvate of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine. The invention provides a method for using such solvate.

Claims

1. A mono(methylene chloride) solvate of a compound of formula I ##STR2##

2. A solvate of claim 1 which is crystalline and has a typical X-ray powder diffraction pattern substantially as follows, using an Enraf-Nonius CAD4 kappa axis diffractometer, wherein d represents the interplanar spacing in Angstroms:

space="preserve" listing-type="tabular">______________________________________ ______________________________________ 10.3721 9.4579 8.0541 7.4887 6.7033 6.5341 5.6880 5.5067 5.2097 4.7905 4.5342 4.3932 4.1624 4.0157 3.9705 3.8522 3.7535 3.6804 3.6335 3.5198 3.489 3.4399 3.3491 3.2431 3.1714 3.1075 3.0437 2.9476 2.8872 2.8466 2.7906 2.7239 2.6859 2.6116 2.5729. ______________________________________