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Methods for optimizing of an optical assay device

  • US 5,639,671 A
  • Filed: 03/28/1995
  • Issued: 06/17/1997
  • Est. Priority Date: 09/18/1989
  • Status: Expired due to Term
First Claim
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1. A method for optimization of a visual signal of an optical assay device for the detection of an analyte, comprising the steps of:

  • (a) providing a substrate having a length and an anti-reflective film thereon with a plurality of thicknesses varied incrementally along the length of said substrate,providing an attachment layer of a chosen thickness on said anti-reflective film,providing a receptive layer of a chosen thickness for the analyte on said attachment layer,(b) contacting said analyte with said receptive layer under conditions such that a mass change on said receptive layer results, and(c) determining one or more thicknesses of said plurality of thicknesses of said anti-reflective film that in combination with the other layers of said device produces a visual signal comprising a maximized visual contrast in interference color upon said change in mass relative to a background interference color, over a range of concentrations of said analyte.

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