Implantable techniques for infusing a therapeutic agent with endogenous bodily fluid

• US 5,643,207 A
• Filed: 06/27/1996
• Issued: 07/01/1997
• Est. Priority Date: 04/28/1995
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Rise, Mark T.
• Primary Examiner(s): Buiz, Michael Powell
• Assistant Examiner(s): GRING, NOELLE K
• Application Number:
  US08/670,297
• Time in Patent Office: 369 Days
• Field of Search: 604/93, 604/19, 604/891.1, 604/48, 604/50, 604/65, 604/66, 604/67, 604/245, 604/246, 120/DIG. 12
• US Class Current: 604/93.01
• CPC Class Codes: A61M 2205/0244 Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
• CPC Class Codes: A61M 5/14276 specially adapted for implantation

Abstract

An implantable system for infusing an agent into an organ containing an endogenous fluid, including an implantable reservoir for the agent and implantable first and second catheters implanted in the organ. An implantable pump transmits the endogenous fluid to the organ through one catheter and returns it through the other catheter. A predetermined quantity of the agent is added from the reservoir to the endogenous fluid to facilitate buffering and dilution of the agent before administration to the organ.

Claims

1. A method for infusing an agent into an organ of a human body using said body'"'"'s own endogenous fluid, said method comprising he steps of:

holding a quantity of said agent inside said body;

collecting a portion of said endogenous fluid;

transmitting a portion of said collected endogenous fluid into said organ; and

adding, within said body from said quantity of said agent, a predetermined dose of said agent to at least a portion of said endogenous fluid transmitted into said organ, whereby the addition of said agent to said endogenous fluid facilitates buffering and dilution of said agent before administration to said organ.

2. A method, as claimed in claim 1, wherein said organ is the brain and said endogenous fluid is cerebrospinal fluid.

3. A method, as claimed in claim 1, wherein said organ is the pancreas and said endogenous fluid is blood plasma.

4. A method, as claimed in claim 1, wherein said step of transferring comprises the step of pumping.

5. A method, as claimed in claim 1, wherein said step of transmitting is conducted substantially continuously.

6. A method, as claimed in claim 5, wherein said step of adding comprises the step of adding said agent periodically, so that said endogenous fluid is transmitted substantially continuously and said agent is transmitted to said organ periodically.

7. A method, as claimed in claim 1, wherein said step of adding comprises the step of mixing said dose of said agent with a predetermined quantity of said endogenous fluid, whereby control of the concentration of said agent in said endogenous fluid is facilitated.

8. A method, as claimed in claim 1, wherein said organ is the brain.

9. A method, as claimed in claim 1, wherein said endogenous fluid is cerebrospinal fluid.

10. A method, as claimed in claim 1, wherein said organ is the pancreas.

11. A method, as claimed in claim 1, wherein said endogenous fluid is blood plasma.

12. A method for infusing an agent into an organ in a body using an endogenous fluid comprising the steps of;

implanting a pump in said body;

fluidly connecting a reservoir to said pump, said reservoir holding a quantity of said agent;

implanting a first catheter in said body, said first catheter having a proximal end fluidly connected to said pump, said first catheter having a distal end implanted in said endogenous fluid;

implanting a second catheter in said body, said second catheter having a proximal end fluidly connected to said pump, said second catheter having a distal end implanted in said organ;

pumping said endogenous fluid through said first catheter from said distal end of said first catheter to said pump;

pumping said endogenous fluid from said pump to said organ through said second catheter; and

adding a predetermined quantity of said agent from said reservoir to at least a portion of said endogenous fluid pumped from said pump to said organ.

13. The method of claim 12 further comprising the step of implanting said reservoir in said body.

14. A method, as claimed in claim 12, wherein said organ is the brain.

15. A method, as claimed in claim 12, wherein said endogenous fluid is cerebrospinal fluid.

16. A method, as claimed in claim 12, wherein said organ is the brain and said endogenous fluid is cerebrospinal fluid.

17. A method, as claimed in claim 12, wherein said organ is the pancreas.

18. A method, as claimed in claim 12, wherein said endogenous fluid is blood plasma.

19. A method, as claimed in claim 12, wherein said organ is the pancreas and said endogenous fluid is blood plasma.

20. An implantable system for infusing an agent into an organ using an endogenous fluid, said system comprising in combination:

an implantable pump;

an implantable reservoir for holding a quantity of said agent, said implantable reservoir in fluid communication with said implantable pump;

an implantable first catheter having a proximal end fluidly connected to said implantable pump, said first catheter having a distal end suitable for implantation in said endogenous fluid;

an implantable second catheter having a proximal end fluidly connected to said implantable pump, said second catheter having a distal end suitable for implantation in said organ;

wherein said implantable pump pumps said endogenous fluid through said first catheter of said distal end of said first catheter to said pump and then pumps said endogenous fluid from said pump to said organ through said second catheter; and

means for adding a predetermined quantity of said agent from said reservoir to at least a portion of said endogenous fluid pumped from said pump to said organ, whereby patency of said first and second catheters is facilitated by flow of said endogenous fluid through said first and second catheters and whereby the addition of said agent to said endogenous fluid facilitates buffering and dilution of said agent before administration to said organ.

21. A system, as claimed in claim 20, wherein said organ is the brain and said endogenous fluid is cerebrospinal fluid.

22. A system, as claimed in claim 20, wherein said organ is the pancreas and said endogenous fluid is blood plasma.

23. A system, as claimed in claim 20, wherein said pump operates substantially continuously.

24. A system, as claimed in claim 23, wherein said means for adding periodically adds said predetermined quantity of said agent to said endogenous fluid, so that said endogenous fluid is substantially continuously delivered to said organ and said agent is periodically delivered to said organ.

25. A system, as claimed in claim 20, wherein said pump includes a chamber for holding a predetermined quantity of said endogenous fluid, wherein said endogenous fluid flows from said first catheter into said chamber, wherein said means for adding transfers said agent from said reservoir to said chamber and wherein said second catheter transfers fluid from said chamber to said organ.

26. A system, as claimed in claim 25, wherein said means for adding comprises a second pump.

27. A system, as claimed in claim 26, wherein said second pump comprises a micromachined pump.

28. A system, as claimed in claim 20, wherein said pump comprises a peristaltic pump.

29. A system, as in claim 20, wherein said means for adding includes a valve controlling the addition of said agent to said endogenous fluid.

30. A system, as claimed in claim 20, wherein said organ is the brain.

31. A system, as claimed in claim 20, wherein said endogenous fluid is cerebrospinal fluid.

32. A system, as claimed in claim 20, wherein said organ is the pancreas.

33. A system, as claimed in claim 20, wherein said endogenous fluid is blood plasma.