Microparticle switching devices for use in implantable reservoirs

• US 5,643,247 A
• Filed: 05/26/1994
• Issued: 07/01/1997
• Est. Priority Date: 01/21/1993
• Status: Expired due to Fees

• Current Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Original Assignee: Mayo Foundation For Medical Education And Research (Mayo Clinic)
• Inventors: Nanavati, Chaya, Fernandez, Julio M.
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US08/249,435
• Time in Patent Office: 1,132 Days
• Field of Search: 604/890.1-892.1, 604/20, 604/30, 604/31, 604/65, 604/93, 604/126, 604/153, 604/169, 604/190, 604/215, 604/245, 604/246, 604/256, 604/250, 137/909, 251/129.01, 251/129.06
• US Class Current: 604/891.1
• CPC Class Codes: A61K 9/127 Liposomes
• CPC Class Codes: A61K 9/1652 Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin homeopathic globules A61K9/1623
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/16813 by controlling the degree of opening of the flow line
• CPC Class Codes: F15C 5/00 Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
• CPC Class Codes: H01G 9/00 Electrolytic capacitors, rectifiers, detectors, switching devices, light-sensitive or temperature-sensitive devices; Processes of their manufacture
• CPC Class Codes: H01G 9/16 specially for use as rectifiers or detectors H01G9/22 takes precedence
• CPC Class Codes: H02N 11/006 Motors

Abstract

A diode device (10) containing a microparticle polymer element (12) is described. Also described are mechanical switching devices that employ the microparticle polymer element.

Claims

1. A switching device for use with a voltage source effective to generate a voltage having a selected polarity, comprising

a polymer-matrix microparticle composed of a matrix of crosslinked polyionic polymer filaments and defining a surface,

a first chamber containing an electrolyte medium that is in contact with an interior surface region of said surface,

a second chamber containing an electrolyte medium that is in contact with an exterior surface region of said surface,

said first chamber and said second chamber being configured such that said interior surface region is substantially less than said exterior surface region, and

electrical connections adapted to connect the electrolyte medium to such a voltage source, for applying across said first chamber and said second chamber, a voltage having a selected voltage level and polarity,

whereby the device allows electric current flow between the first chamber and the second chamber when the voltage has one of two possible polarities, and substantially blocks current flow between the first chamber and the second chamber the other of two possible polarities.

2. The switching device of claim 1, wherein said first chamber and said second chamber are separated by an opening defining an interior solid angle and an exterior solid angle subtending interior and exterior sides of the opening, respectively, and said interior solid angle is substantially less than said exterior solid angle.

3. The switching device of claim 2, wherein application of a given voltage causes the electric current flow to reach a half-maximal value, for the given voltage, within about 30 msec of said application, when the voltage applied is between ±

0.5 to 5 volts.

4. The switching device of claim 2, for use as a miniature, implantable drug-delivery device for dispensing a drug, which further includes a drug reservoir having a flexible drug-outlet tube which is open when the polymer-matrix microparticle is in its condensed condition and closed when the polymer-matrix microparticle is in its decondensed condition.

5. The switching device of claim 2, for use as a miniature pump, which further includes a flexible pumping tube which is alternately squeezed and released as the polymer-matrix microparticle is switched between its decondensed and condensed states, respectively.

6. The switching device of claim 1, wherein said interior surface region is at least 25 times that of the exterior surface region.

7. The switching device of claim 1, wherein the electrolyte medium contains a multivalent solute species effective to condense said polymer-matrix microparticle, in the absence of an electric field, and said polymer-matrix microparticle is decondensed in the presence of a voltage whose polarity is effective to allow electric current flow.

8. The switching device of claim 7, wherein said polymer-matrix microparticle has a dimension between about 0.5 and 5.0 μ

m.

9. The switching device of claim 1, wherein the crosslinked polyionic polymer filaments forming the matrix are polyanionic polymer filaments.

10. The switching device of claim 9, wherein the crosslinked polyionic polymer filaments forming the matrix are sulfated, sulfonated, carboxylated, or phosphated filaments.

11. The switching device of claim 10, wherein the matrix is composed of crosslinked comb-polymer glycoproteins.