Biocompatible coated article

• US 5,643,681 A
• Filed: 06/07/1995
• Issued: 07/01/1997
• Est. Priority Date: 04/15/1994
• Status: Expired due to Term

• Current Assignee: Cobe Cardiovascular Incorporated (LivaNova Plc)
• Original Assignee: Cobe Cardiovascular Incorporated (LivaNova Plc)
• Inventors: Voorhees, Marc, Fisher, Harold, Forrestal, Lloyd
• Primary Examiner(s): Nakarani, D. S.
• Application Number:
  US08/473,723
• Time in Patent Office: 755 Days
• Field of Search: 428/308.4, 428/315.5, 428/315.9, 428/319.3, 428/319.7, 428/423.7, 428/425.5, 428/447, 428/451, 428/480, 428/483
• US Class Current: 428/483
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 33/068 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L33/062 takes precedence
• CPC Class Codes: B01D 67/0088 Physical treatment with compounds, e.g. swelling, coating or impregnation
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: C08L 83/10 Block- or graft-copolymers containing polysiloxane sequences obtained by polymerising a compound having a carbon-to-carbon double bond on to a polysiloxane C08L51/08, C08L53/00
• CPC Class Codes: C09D 183/10 Block or graft copolymers containing polysiloxane sequences obtained by polymerising a compound having a carbon-to-carbon double bond on to a polysiloxane C09D151/08, C09D153/00
• CPC Class Codes: Y10T 428/249978 Voids specified as micro
• CPC Class Codes: Y10T 428/24998 Composite has more than two layers
• CPC Class Codes: Y10T 428/249992 Linear or thermoplastic
• CPC Class Codes: Y10T 428/31663 As siloxane, silicone or silane
• CPC Class Codes: Y10T 428/31667 Next to addition polymer from unsaturated monomers, or aldehyde or ketone condensation product
• CPC Class Codes: Y10T 428/31681 Next to polyester, polyamide or polyimide [e.g., alkyd, glue, or nylon, etc.]
• CPC Class Codes: Y10T 428/31786 Of polyester [e.g., alkyd, etc.]
• CPC Class Codes: Y10T 428/31797 Next to addition polymer from unsaturated monomers

Abstract

The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylactone type. Optimum biocompatibility is provided by a coating of optimum surface concentration. Porous membranes can be coated as described, providing improved biocompatibility of blood oxygenators, hemodialyzers and the like.

Claims

1. A polymeric article having a base polymer and a biocompatible coating thereon comprising a polylactone-polysiloxane-polylactone triblock copolymer, said coating having a relative surface concentration sufficient to provide an X-ray fluorescence intensity ratio in the range 0.1 to 0.25.

2. A polymeric article according to claim 1 wherein the X-ray fluorescence intensity ratio is in the range 0.14 to 0.22.

3. A polymeric article according to claim 1 wherein said base polymer is a polypropylene membrane.

4. A polymeric article according to claim 1 wherein said base polymer is a polyethylene membrane.

5. A polymeric article according to claim 1 wherein the triblock copolymer is a polycaprolactone-polysiloxane-polycaprolactone copolymer.

6. A polymeric article according to claim 5 wherein the triblock copolymer comprises polycaprolactone blocks having each a nominal molecular weight in the range 1000 to 10,000 and a polysiloxane block having a nominal molecular weight in the range 1000 to 5000.

7. A polymeric article according to claim 6 wherein the triblock copolymer comprises polycaprolactone blocks having a nominal molecular weight of 2000 and a polysiloxane block having a nominal molecular weight in the range 2000-3000.

8. A polymeric article having a base polymer and a biocompatible coating thereon comprising a polylactone-polysiloxane-polylactone triblock copolymer, said coating having a relative surface concentration sufficient to provide an X-ray fluorescence intensity ratio in the range 0.02 to 0.35.

9. A polymeric article according to claim 8 wherein the X-ray fluorescence intensity ratio is in the range 0.05 to 0.25.

10. A polymeric article according to claim 8 wherein the X-ray fluorescence intensity ratio is in the range 0.16 to 0.20.

11. A polymeric article according to claim 8 wherein said base polymer is a polypropylene membrane.

12. A polymeric article according to claim 8 wherein said base polymer is a polyethylene membrane.