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Methods for diagnosing cancer, precancerous state, or susceptibility to other forms of diseases by detecting an acceleration of exon skipping in IRF-1 mRNA

  • US 5,643,729 A
  • Filed: 02/24/1995
  • Issued: 07/01/1997
  • Est. Priority Date: 02/24/1994
  • Status: Expired due to Fees
First Claim
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1. A method for detecting an acceleration of exon skipping in interferon-regulatory factor-1 (IRF-1) mRNA, the method comprising:

  • (a) assaying IRF-1 mRNA level in a first biological sample, wherein said IRF-1. mRNA is selected from one or more of intact IRF-1 mRNA, Δ

    2 IRF-1 mRNA, or Δ

    23 IRF-1 mRNA;

    (b) comparing said IRF-1 mRNA level to an IRF-1 mRNA standard level, said standard being taken from a second biological sample not exhibiting accelerated exon skipping in IRF-1 mRNA; and

    (c) determining whether said sample exhibits an acceleration of exon skipping in IRF-1 mRNA.

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