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Method of synthesis of plurality of compounds in parallel using a partitioned solid support

  • US 5,643,738 A
  • Filed: 05/31/1995
  • Issued: 07/01/1997
  • Est. Priority Date: 11/10/1994
  • Status: Expired due to Term
First Claim
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1. A method of synthesizing a plurality of proteins or oligonucleotides in parallel which comprises,providing a substrate having a plurality of wells, each well connected to a plurality of reservoirs for reagents or solvents, which reservoirs are formed in the substrate, the reservoirs connected to said wells by one or more channels, wherein the channel(s) connected to a particular reservoir do not intersect with channel(s) connected to other reservoirs so that reagents and solvents are controllably mixed in the wells;

  • moving reagents or solvents in sequence from said reservoirs along said channels and into and out of said wells by means of electrokinetic pumps each connected to a driver means; and

    reacting said reagents to form a plurality of proteins or oligonucleotides.

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