Method and device for monitoring and detecting sympatho-vagal activity and for providing therapy in response thereto
First Claim
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1. A method of providing therapy to a patient comprising:
- implanting at least one sensor in the proximity of the patient'"'"'s heart;
sensing the electrical activity of the patient'"'"'s heart from the at least one sensor;
generating an electrocardiology signal from the sensed electrical activity of the patient'"'"'s heart;
repeatedly calculating from the signal a time differential between consecutive R-R intervals;
comparing the time differentials with a predetermined time differential threshold value;
counting the number of time differentials which exceed the predetermined time differential threshold value during a predetermined time interval, that number being equal to the number of useful events;
determining whether the number of useful events lies within a predetermined band of normal values; and
providing therapy to the patient if the number of useful events does not lie within the predetermined band of normal values.
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Abstract
A device for controlling therapeutic means acting on a patient comprises means for detecting the sympatho-vagal balance of the patient and processor means for generating a control signal for the therapeutic means combined in a circuit assembly which allows the device to be implanted in the body of said patient.
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Citations
53 Claims
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1. A method of providing therapy to a patient comprising:
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implanting at least one sensor in the proximity of the patient'"'"'s heart; sensing the electrical activity of the patient'"'"'s heart from the at least one sensor; generating an electrocardiology signal from the sensed electrical activity of the patient'"'"'s heart; repeatedly calculating from the signal a time differential between consecutive R-R intervals; comparing the time differentials with a predetermined time differential threshold value; counting the number of time differentials which exceed the predetermined time differential threshold value during a predetermined time interval, that number being equal to the number of useful events; determining whether the number of useful events lies within a predetermined band of normal values; and providing therapy to the patient if the number of useful events does not lie within the predetermined band of normal values. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A device for providing therapy to a patient comprising:
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means for implantation within the patient for sensing the electrical activity of the patient'"'"'s heart; means for generating an electrocardiology signal from the sensed electrical activity of the patient'"'"'s heart; means for repeatedly calculating from the signal a time differential between consecutive R-R intervals; means for comparing the time differentials with a predetermined time differential threshold value; means for counting the number of time differentials which exceed the predetermined time differential threshold value during a predetermined time interval, that number being equal to the number of useful events; means for determining whether the number of useful events lies within a predetermined band of normal values; and means for providing therapy to the patient if the number of useful events does not lie within the predetermined band of normal values. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A device for providing therapy to a patient comprising:
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at least one sensor sized for implantation within the patient having an output indicative of the electrical activity of the patient'"'"'s heart; a signal generator connected to receive the output of the at least one sensor and responsive thereto to generate an electrocardiology signal; a processor connected to receive the cardiology signal and to; a) repeatedly calculate from the signal a time differential between consecutive R-R intervals; b) compare the time-differentials with a predetermined time differential threshold value; c) count the number of time differentials which exceed the predetermined time differential threshold value during a predetermined time interval, that number being equal to the number of useful events; and d) determine whether the number of useful events lies within a predetermined band of normal values; the processor producing an output signal indicative of the sympatho-vagal activity of the patient'"'"'s heart; and a therapy dispenser responsive to the processor output signal to dispense therapy to the patient if the number of useful events does not lie within the predetermined band of normal values. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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Specification