Low voltage miniaturized column analytical apparatus and method
First Claim
1. A miniaturized column analytical apparatus comprising:
- (a) a miniaturized column device comprising;
(i) a body having an elongate separation compartment having first and second opposing sides along the elongate dimension;
(ii) two or more sets of spaced apart antennas positioned along the opposing sides of the separation compartment, each set containing a plurality of antennas, one antenna from each set being associated with at least one antenna from each of the other sets to form repeating sequences of antennas along the separation compartment on said sides of the separation compartment, each set of the antennas being associated with a different oscillating alternating current electrical potential to provide a plurality of oscillating electric fields along the elongate separation compartment to draw a target substance along said elongate separation compartment toward an exit end thereof, and(b) a detector for detecting the target substance passing through the elongate separation compartment.
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Accused Products
Abstract
A miniaturized column analytical apparatus having a miniaturized column device containing a body with an elongate separation compartment is provided. Two or more sets of spaced apart antennas are positioned along the elongate separation compartment. The elongate separation compartment has first and second opposing sides along its elongate dimension. Each set of antenna contains a plurality of antennas. One antenna from each set is associated with at least one antenna from each of the other sets to form repeating sequences of antennas along the separation compartment on the opposing sides of the separation compartment. Each set of the antennas is associated with a different oscillating electrical potential to provide a plurality of oscillating electric fields along the elongate separation compartment to draw a target substance along the elongate separation compartment toward an exit end of the separation compartment. The detector can detect a target substance passing out of the elongate separation compartment.
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Citations
30 Claims
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1. A miniaturized column analytical apparatus comprising:
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(a) a miniaturized column device comprising; (i) a body having an elongate separation compartment having first and second opposing sides along the elongate dimension; (ii) two or more sets of spaced apart antennas positioned along the opposing sides of the separation compartment, each set containing a plurality of antennas, one antenna from each set being associated with at least one antenna from each of the other sets to form repeating sequences of antennas along the separation compartment on said sides of the separation compartment, each set of the antennas being associated with a different oscillating alternating current electrical potential to provide a plurality of oscillating electric fields along the elongate separation compartment to draw a target substance along said elongate separation compartment toward an exit end thereof, and (b) a detector for detecting the target substance passing through the elongate separation compartment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A miniaturized column device for moving a target substance through an elongate compartment comprising:
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(i) a substrate having first and second substantially planar surfaces facing away from each other, said substrate having a microchannel in the first planar surface; (ii) a cover member arranged over the first planar surface, said cover member in combination with the microchannel defining the elongate compartment, said elongate compartment having first and second opposing sides along its elongate dimension; and (iii) two or more sets of spaced apart antennas positioned along the opposing sides of the compartment, each set containing a plurality of antennas, one antenna from each set being associated with at least one antenna from each of the other sets to form repeating sequences of antennas along the elongate compartment at said opposing sides such that any two neighboring antennas from the same side and the antenna from the opposing side closest to said two neighboring antennas are in a triangular configuration, each set of the antennas being associated with a different oscillating electrical potential to provide a plurality of oscillating electric fields along the elongate compartment to draw the target substance along said elongate compartment.
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20. A method for analyzing a target substance, comprising:
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(a) placing the target substance in a miniaturized elongate compartment; (b) providing a different oscillating alternating current electrical potential on each of two or more sets of antennas along the elongate compartment to result in a plurality of oscillating electric fields to draw the target substance along the elongate compartment; and (c) detecting the target substance proximate an exit end of the elongate compartment. - View Dependent Claims (21, 22, 23)
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24. A method for making a miniaturized column device, comprising:
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(a) micromachining a substrate having first and second substantially planar surfaces facing away from each other to result in a microchannel in the first planar surface; (b) arranging over the first planar surface a cover member which in combination with the microchannel defining an elongate separation compartment having first and second opposing sides along an elongate separation dimension and positioning two or more sets of spaced apart antennas along the opposing sides of the separation compartment, each set containing a plurality of antennas, one antenna from each set being associated with at least one antenna from each of the other sets to form repeating sequences of antennas along the separation compartment at said opposing sides; and (c) connecting a power supply means to the antennas such that each set of the antennas is associated with a different oscillating alternating current electrical potential to result in a plurality of oscillating electric fields along the elongate separation compartment capable of drawing a target substance along said elongate separation compartment so that the target substance can be detected proximate an exit end of the elongated separation compartment. - View Dependent Claims (25)
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26. A miniaturized column analytical apparatus comprising:
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(a) a miniaturized column device comprising; (i) a body having an elongate separation compartment having first and second opposing sides along the elongate dimension; (ii) two or more sets of spaced apart antennas positioned along the opposing sides of the separation compartment, each set containing a plurality of antennas, one antenna from each set being associated with at least one antenna from each of the other sets to form repeating sequences of antennas along the separation compartment on said sides of the separation compartment, each set of the antennas being associated with a different oscillating electrical potential to provide a plurality of oscillating electric fields along the elongate separation compartment to draw a target substance along said elongate separation compartment toward an exit end thereof, wherein each set of antennas has two subsets each having electrical potential that is a mirror image of the other in amplitude; and (b) a detector for detecting the target substance passing through the elongate separation compartment. - View Dependent Claims (27, 28, 29)
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30. A method for analyzing a target substance, comprising:
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(a) placing the target substance in a miniaturized elongate compartment having opposing sides and a downstream direction; (b) providing a different oscillating electrical potential on each of two or more sets of antennas along the elongate compartment to result in a plurality of oscillating electric fields to draw the target substance along the elongate compartment, such that the electrical potential of an antenna leads the electrical potential of the antenna closest and downstream thereto on the opposing side by a phase difference of 180°
/n, where n is the number of sets of antennas so that the antennas on the two opposing sides form a repeating sequence of phase difference; and(c) detecting the target substance proximate an exit end of the elongate compartment;
wherein the elongate compartment, the antennas being positioned along the opposing sides.
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Specification