Specimen processing and analyzing systems with associated fluid dispensing apparatus

• US 5,645,800 A
• Filed: 06/02/1995
• Issued: 07/08/1997
• Est. Priority Date: 10/31/1991
• Status: Expired due to Term

• Current Assignee: Beckman Coulter Incorporated (Danaher Corporation)
• Original Assignee: Dade Microscan, Inc.
• Inventors: Campbell, Randolph L., Daniel, Craig M., Masterson, Brian K.
• Primary Examiner(s): Le, Long V.
• Application Number:
  US08/458,315
• Time in Patent Office: 767 Days
• Field of Search: 422/63, 422/64, 422/65, 422/67, 422/100, 422/104, 436/43, 436/47, 436/48, 436/49, 436/180, 436/807, 436/809, 435/809
• US Class Current: 422/65
• CPC Class Codes: G01N 2035/0425 Stacks, magazines or elevators for plates
• CPC Class Codes: G01N 35/028 having reaction cells in the form of microtitration plates
• CPC Class Codes: G01N 35/1002 Reagent dispensers
• CPC Class Codes: Y10S 435/809 Incubators or racks or holders for culture plates or containers
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/111666 Utilizing a centrifuge or compartmented rotor
• CPC Class Codes: Y10T 436/113332 with conveyance of sample along a test line in a container or rack
• CPC Class Codes: Y10T 436/114998 with treatment or replacement of aspirator element [e.g., cleaning, etc.]
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

A system for processing a specimen to which fluid must be added includes a fluid dispensing work station within a housing. The work station holds the fluids that are to be added to the specimen. A nozzle dispenses fluid at the work station. The system also includes a carrier that moves within the housing. The carrier operates in a first mode at the fluid dispensing work station. The carrier also operates in a second mode outside the work station to perform a different processing function. A coupling mechanism attaches the nozzle to the carrier when the carrier enters its first operational mode to transport the nozzle around the fluid dispensing station. The coupling mechanism releases the nozzle from the carrier when the carrier enters its second operational mode, thereby freeing the carrier for movement outside the work station out of association with the nozzle.

Claims

1. A specimen incubator comprising:

means defining an axially elongate vertically extending annular incubation volume for receiving and incubating plural specimens therein;

means for environmental control of said incubation volume;

support structure extending vertically within said annular incubation volume;

a carrier member movable vertically on said support structure, said carrier member also being movable horizontally from within said annular incubation volume outwardly into said incubation volume to extract therefrom and replace there into a selected one of said plural specimens;

detection means associated with said carrier member for detecting a physical response of said selected specimen; and

fluid dispensing means disposed vertically outside of and axially adjacent to said incubation volume, said support structure extending vertically outside of said incubation volume and to traverse said fluid dispensing means, and said carrier member being movable vertically on said support structure outside of said annular incubation volume and to said fluid dispensing means, whereby said carrier member is movable on said support structure to said fluid dispensing means to deliver said selected specimen to said fluid dispensing means.

2. The specimen incubator of claim 1 wherein said fluid dispensing means includes a fluid dispensing nozzle movable within said fluid dispensing means, and each of said carrier member and said nozzle including cooperating coupling means for coupling said fluid dispensing nozzle with said carrier member and supportingly moving said fluid dispensing nozzle with said carrier member.

3. The specimen incubator of claim 2 further including a fluid source in fluid flow communication with said fluid dispensing nozzle;

said fluid source being disposed in general axial alignment with said incubation volume, outside of said incubation volume, and at a vertical level generally coextensive with said fluid dispensing means.

4. The specimen incubator of claim 3 wherein said fluid dispensing nozzle of said fluid dispensing means is separated from said fluid source by a distance not greater than the radius of said annular incubation volume.

5. The specimen incubator of claim 3 wherein said fluid source includes means for applying pressurized gas to a fluid held within said fluid source, said pressurized gas being applied to said fluid at a pressure less than 8 psig.

6. The specimen incubator of claim 5 wherein said pressurized gas is applied to said source fluid at a pressure of substantially 3 psig.