Chewing gum compositions and the use thereof for remineralization of lesions in teeth

• US 5,645,853 A
• Filed: 08/08/1995
• Issued: 07/08/1997
• Est. Priority Date: 08/08/1995
• Status: Expired due to Fees

• Current Assignee: Church & Dwight Company Incorporated
• Original Assignee: Enamelon Incorporated
• Inventors: Usen, Norman, Winston, Anthony E.
• Primary Examiner(s): Le, Hoa Van
• Application Number:
  US08/512,286
• Time in Patent Office: 700 Days
• Field of Search: 424/48, 424/52, 424/57, 424/440, 514/782, 426/3
• US Class Current: 424/440
• CPC Class Codes: A61K 2800/88 Two- or multipart kits
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

This invention relates to chewing gum compositions and methods utilizing same which are useful to remineralize subsurface dental enamel. More specifically, this invention relates to stable, single-part chewing gum compositions containing calcium and phosphate salts which when applied to lesions in dental enamel result in remineralization of subsurface dental enamel and/or mineralization of tubules in dentin thereby counteracting caries and/or hypersensitivity.

Claims

1. A chewing gum product for remineralizing at least one subsurface lesion and/or mineralizing at least one exposed dentinal tubule in at least one tooth, comprising:

(i) a water-soluble cationic portion comprising from about 0.01% to 15.0% of at least one water-soluble calcium salt;

(ii) a water-soluble anionic portion comprising from about 0.01% to 15.0% of at least one water-soluble phosphate salt;

(iii) from about 10.0% to 95.0% of a gum base; and

(iv) at least one encapsulating coating disposed on one or both of said cationic and anionic portions, wherein said encapsulating coating is present in an amount and is comprised of a material such that (a) said encapsulating coating substantially inhibits reaction of said cationic and anionic portions during storage of said product, and (b) when said product is chewed and contacted with saliva, said encapsulating coating releases said encapsulated cationic and/or anionic portion at a rate such that said cationic and anionic portions of said product are simultaneously released into said saliva, thereby forming a mixed aqueous solution which comprises cations released by said cationic portion and anions released by said anionic portion and further which simultaneously delivers said cations and anions to a surface of said tooth, said cationic and anionic portions each having a pH in water such that said mixed aqueous solution has a pH of from about 4.0 to 7.0.

2. The chewing gum product according to claim 1, wherein said cationic and anionic portions are each coated with said at least one encapsulating coating, further wherein said encapsulating coating disposed on said cationic portion and said encapsulating coating disposed on said anionic portion constitute identical materials.

3. The chewing gum product according to claim 2, wherein said encapsulating coating disposed on said cationic portion and said encapsulating coating disposed on said anionic portion constitute identical materials having substantially identical thicknesses.

4. The chewing gum product according to claim 1, wherein said at least one encapsulating coating has a thickness of from about 0.1 to 20 microns.

5. The chewing gum product of claim 1, wherein said at least one encapsulating coating comprises a material selected from the group consisting of oleophilic materials, edible materials, polymeric materials, resin materials, waxes and mineral oils.

6. The chewing gum product according to claim 5, wherein said at least one encapsulating coating is a polymeric material selected from the group consisting of hydrophilic organic polymers, hydrophobic organic polymers and mixtures thereof.

7. The chewing gum product according to claim 6, wherein said polymeric material is a hydrophilic polymer selected from the group consisting of water-soluble organic polymers and water-dispersible organic polymers.

8. The chewing gum product according to claim 7, wherein said hydrophilic polymer is selected from the group consisting of gum arabic, gum karaya, gum tragacanth, guar gum, locust bean gum, xanthan gum, carrageenan, alginate salt, casein, dextran, pectin, agar, sorbitol, 2-hydroxyethyl starch, 2-aminoethyl starch, maltodextrin, amylodextrin, 2-hydroxyethyl cellulose, methyl cellulose, carboxymethyl cellulose salt, cellulose sulfate salt, polyvinylpyrrolidone, polyethylene glycol, polypropylene glycol, polyethylene oxide and polyvinyl alcohol/acetate.

9. The chewing gum product according to claim 7, wherein said hydrophilic polymer is selected from the group consisting of a polyethylene glycol having a molecular weight of 4000, a polyvinylpyrrolidone, a polyethylene oxide having a molecular weight of 4,000,000, and a partially hydrolyzed polyvinyl acetate.

10. The chewing gum product according to claim 6, wherein said polymeric material is a hydrophobic organic polymer selected from the group consisting of polyvinyl acetate, polyacrylamide, polyvinyl chloride, polystyrene, polyethylene, and polyurethane.

11. The chewing gum product according to claim 10, wherein said hydrophobic polymer comprises from about 5.0% to 30.0% by weight of a particulate water-extractable organic or inorganic filler.

12. The chewing gum product according to claim 5, wherein said at least one encapsulating coating comprises a polymeric material which is applied to said anionic and/or cationic portion by a process selected from the group consisting of pan coating, fluidized coating and centrifugal fluidized coating.

13. The chewing gum product according to claim 5, wherein said at least one encapsulating coating comprises a polymeric material which is applied to said anionic and/or cationic portion in the form of an emulsion or suspension, wherein after application to said cationic and anionic portions, said emulsion or suspension undergoes evaporation so as to remove a solvent medium thereof to form a continuous film coating which encapsulates said cationic and anionic portions.

14. The chewing gum product according to claim 5, wherein said at least one encapsulating coating comprises a polymeric material which constitutes from about 5.0 to about 50.0 percent of the combined dry weight of the coated cationic and anionic portions.

15. The chewing gum product according to claim 5, wherein said at least one encapsulating coating is an oleophilic material selected from the group consisting of paraffin, mineral oil, edible oils, organic esters and edible polysiloxanes.

16. The chewing gum product according to claim 15, wherein said oleophilic material is an edible oil selected from the group consisting of peanut oil, coconut oil, palm oil, and safflower oil.

17. The chewing gum product according to claim 15, wherein said oleophilic material is an organic ester selected from the group consisting of isopropyl siloxane myristate, and isopropyl palmitate.

18. The chewing gum product according to claim 5, wherein said at least one encapsulating coating comprises an edible gum.

19. The chewing gum product according to claim 1 wherein the chewing gum product contains from about 0.0001% to 0.5% of at least one water-soluble fluoride salt which yields fluoride ions.

20. The chewing gum product according to claim 1 wherein the encapsulating coating comprises between about 5.0% to 50.0% of the surface-coated calcium, phosphate, or fluoride salt particle dry weight.

21. The chewing gum product according to claim 1 wherein the encapsulating coating is a hydrophilic polymer or water-insoluble polymer or a mixture thereof.

22. The chewing gum product according to claim 1 wherein the encapsulating surface-coating on the calcium, phosphate, or fluoride salt particles is a hydrophilic polymer having a content between about 5.0% to 95.0% of a water-insoluble polymer, based on the coating weight.

23. The chewing gum product according to claim 1 wherein the encapsulating polymer is a hydrocolloid.

24. The chewing gum product according to claim 1 wherein the encapsulating polymer is polyvinyl acetate.