Cross-linked polyethylene oxide coatings to improve the biocompatibility of implantable medical devices
First Claim
1. A method of producing a polyethyleneoxide-coated implantable medical device which is to be sterilized using ethylene oxide, wherein the method comprises(a) modifying the surface of the medical device in a heptylamine gas plasma;
- (b) exposing the modified surface to a buffered solution of an aldehyde terminated-polyethyleneoxide having a molecular weight of about 8000 and sodium cyanoborohydride for a time sufficient to covalently bind the terminal aldehyde of the polyethyleneoxide to the modified surface; and
(c) exposing the bound polyethyleneoxide to an argon plasma for a time sufficient to cause the polyethyleneoxide to form a cross-linked, insoluble network; and
(d) sterilizing the medical device using ethylene oxide.
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Accused Products
Abstract
Polyethylene oxide (PEO) coatings providing improved biocompatibility for implantable medical devices are disclosed. The PEO coatings comprise functionalized end-capped PEO which is attached at one end to the medical device. The PEO compounds are then exposed to a high energy source for a time sufficient to cause the PEO compounds to form a cross-linked, insoluble network. These PEO coatings am able to survive ethylene oxide sterilization procedures with minimal loss of protein or cell repulsion ability.
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Citations
1 Claim
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1. A method of producing a polyethyleneoxide-coated implantable medical device which is to be sterilized using ethylene oxide, wherein the method comprises
(a) modifying the surface of the medical device in a heptylamine gas plasma; -
(b) exposing the modified surface to a buffered solution of an aldehyde terminated-polyethyleneoxide having a molecular weight of about 8000 and sodium cyanoborohydride for a time sufficient to covalently bind the terminal aldehyde of the polyethyleneoxide to the modified surface; and (c) exposing the bound polyethyleneoxide to an argon plasma for a time sufficient to cause the polyethyleneoxide to form a cross-linked, insoluble network; and (d) sterilizing the medical device using ethylene oxide.
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Specification