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Cross-linked polyethylene oxide coatings to improve the biocompatibility of implantable medical devices

  • US 5,645,882 A
  • Filed: 11/29/1995
  • Issued: 07/08/1997
  • Est. Priority Date: 11/16/1994
  • Status: Expired due to Fees
First Claim
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1. A method of producing a polyethyleneoxide-coated implantable medical device which is to be sterilized using ethylene oxide, wherein the method comprises(a) modifying the surface of the medical device in a heptylamine gas plasma;

  • (b) exposing the modified surface to a buffered solution of an aldehyde terminated-polyethyleneoxide having a molecular weight of about 8000 and sodium cyanoborohydride for a time sufficient to covalently bind the terminal aldehyde of the polyethyleneoxide to the modified surface; and

    (c) exposing the bound polyethyleneoxide to an argon plasma for a time sufficient to cause the polyethyleneoxide to form a cross-linked, insoluble network; and

    (d) sterilizing the medical device using ethylene oxide.

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