Adhesive base material

• US 5,646,221 A
• Filed: 03/25/1996
• Issued: 07/08/1997
• Est. Priority Date: 03/31/1995
• Status: Expired due to Fees

• Current Assignee: KOWA Company Limited
• Original Assignee: KOWA Company Limited
• Inventors: Kanebako, Makoto, Inagi, Toshio
• Primary Examiner(s): Zitomer, Fred
• Application Number:
  US08/622,288
• Time in Patent Office: 470 Days
• Field of Search: 526/238.23, 526/238.2, 527/314, 527/300
• US Class Current: 526/238.23
• CPC Class Codes: A61K 9/7061 Polyacrylates
• CPC Class Codes: A61L 15/24 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: C08L 33/06 of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
• CPC Class Codes: C09J 133/062 Copolymers with monomers not covered by C09J133/06

Abstract

An adhesive base material comprises a polymer obtained by polymerizing a glucosyloxy alkyl (meth)acrylate, a hydroxyalkyl (meth)acrylate, an alkyl (meth)acrylate and a polyfunctional monomer. This adhesive base material can be caused to swell uniformly because of its good swelling property and exhibits excellent adhesion to the skin so that it is useful as adhesive layers in plasters, various medical pads and also medicament-impregnated dermatologic medicines.

Claims

1. An adhesive base material comprising a polymer obtained by polymerizing a glucosyloxy alkyl (meth)acrylate, a hydroxyalkyl (meth)acrylate, an alkyl (meth)acrylate and a polyfunctional monomer, and wherein a molar ratio of the glucosyloxy alkyl (meth)acrylate, hydroxyalkyl (meth)acrylate and alkyl (meth)acrylate falls within a range of 0.1-10:

10-40;

5-20.

2. An adhesive base material according to claim 1, wherein a molar ratio of the polyfunctional monomer and the sum of the glucosyloxy alkyl (meth)acrylate, hydroxy alkyl(meth)acrylate and alkyl(meth)acrylate falls within a range of from 1:

100 to 1;

3200.

3. An adhesive base material according to claim 1 comprising a polymer obtained by polymerizing 2-glucosyloxyethyl (meth)acrylate, 2-hydroxyethyl (meth)acrylate, n-butyl (meth)acrylate and ethylene glycol di(meth)acrylate.

4. An adhesive base material according to any one of claims 1, 2 or 3, wherein the polymer has been impregnated with a mixed solvent of an alcohol and water.

5. An adhesive base material according to claim 4, wherein the polymer has been impregnated with a mixed solvent of a polyhydric alcohol, a monohydric alcohol and water.

6. An adhesive base material according to claim 5, wherein the polyhydric alcohol, a monohydric alcohol and water have been mixed at a weight ratio of 0.5-5:

0.1-2;

1.

7. An adhesive base material according to claim 4, wherein the polymer has been pulverized.

8. An adhesive base material according to claim 7, wherein the alcohol and water have been mixed at a weight ratio of from 1:

1 to 1;

10.

9. An adhesive base material according to claim 8, wherein the polymer impregnated and swelled with the solvent has a swelling rate of at least 300%.

10. An adhesive base material according to claim 9, wherein the polymer has peel strength of at least 80 g/cm² when measured relative to glass.

11. A dermatologic medicine comprising an adhesive base material according to claim 1 and a medicament.

12. A dermatologic medicine according to claim 11, wherein the medicament is any one of an antipyretic, antiphlogistic and analgesic agent, a steroidal anti-inflammatory agent, a vasodilator, an antihypertensive and antiarrhythmic agent, a hypotensive agent, an antitussive expectorant, an antineoplastic, a local anesthetic, a hormone preparation, an antiasthmatic and antiallergic agent, an antihistaminic, an anticoagulant, an antispasmodic, a cerebral circulation and metabolism improver, an antidepressant and antianxiety agent, a vitamin D preparation, a hypoglycemic agent, an antiulcer agent, a hypnotic and an antibiotic.