Ambulatory clearance function monitor
First Claim
Patent Images
1. A device for measuring depletion of a detectable substance from a subject, comprising:
- a detector having means for responding to a signal generated from a substance equilibrated within a subject'"'"'s extracellular fluid;
at least one barrier enclosing the detector and at least a portion of a body part of the subject, the barrier defining a constant volume of extracellular fluid within which the signal is detected, said at least one barrier adapted to prevent a signal external to the constant volume portion from reaching the detector; and
signal processing means for determining a clearance rate of the detectable substance, the signal processing means capable of measuring depletion of a quantity of said detectable substance within the defined constant volume of extracellular fluid.
1 Assignment
0 Petitions
Accused Products
Abstract
Accurate and continuous monitoring of clearance function is obtained by determining the depletion of a labelled substance from the extracellular body fluid using an external monitor which detects from within the defined tissue volume. The detector of the external monitor is contained within a barrier which functions to both exclude external influences and to functionally isolate the volume of extracellular fluid to be monitored.
39 Citations
38 Claims
-
1. A device for measuring depletion of a detectable substance from a subject, comprising:
-
a detector having means for responding to a signal generated from a substance equilibrated within a subject'"'"'s extracellular fluid; at least one barrier enclosing the detector and at least a portion of a body part of the subject, the barrier defining a constant volume of extracellular fluid within which the signal is detected, said at least one barrier adapted to prevent a signal external to the constant volume portion from reaching the detector; and signal processing means for determining a clearance rate of the detectable substance, the signal processing means capable of measuring depletion of a quantity of said detectable substance within the defined constant volume of extracellular fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
-
-
23. A portable device for measuring depletion of a detectable substance from a subject comprising:
-
a subject including a delectable substance; a barrier having an elongated sheet capable of defining a volume of extracellular fluid when wrapped around an arm, the sheet having a width sufficient to encompass only a part of the arm and length sufficient to wrap around the arm, said barrier having a portion adapted to house a detector and a device for signal processing; a detector dispersed within said portion for responding to a signal generated from a substance within the defined volume of extracellular fluid; and a signal processing means dispersed within said portion for determining a clearance rate of the detectable substance by measuring depletion over time of a quantity of said detectable substance within the defined volume of extracellular fluid. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31)
-
-
32. A device for measuring renal clearance of a detectable substance from a subject, comprising:
-
a detector having means for responding to a signal generated from a substance equilibrated within a subject'"'"'s extracellular fluid; at least one barrier enclosing the detector and at least a portion of a body part of subject body part, the barrier defining a constant volume of extracellular fluid within which the signal is detected, said at least one barrier adapted to prevent a signal external to the constant volume portion from reaching the detector; and signal processing means for determining a renal clearance rate of the detectable substance, the signal processing means adapted to;
(i) obtain a first measurement of a quantity of said detectable substance at a first time, (ii) obtain a second measurement of a quantity of said detectable substance at a second time, (iii) determine a slope of the first and second measurements over a time interval and (iv) determine and express a clearance rate of said detectable substance using the slope of the first and second measurements within several minutes of said first measurement.
-
-
33. A device for measuring depletion of a detectable substance from a subject, comprising:
-
a detector responsive to a signal generated from a detectable substance equilibrated within a subject'"'"'s extracellular fluid; at least one barrier enclosing the detector and at least a portion of a body part of the subject, the barrier defining a volume of extracellular fluid within which the signal is detected, said at least one barrier adapted to prevent a signal external to the volume portion from reaching the detector; and signal processing means for determining a clearance rate of the detectable substance by measuring depletion of a quantity of said detectable substance within the defined volume of extracellular fluid further comprising a second detector responsive to a signal generated from a second detectable substance within the defined volume of extracellular fluid, wherein the signal froth the second detectable substance indicates a change in the defined volume of extracellular fluid. - View Dependent Claims (35)
-
-
34. A device for measuring depletion of a detectable substance from a subject, comprising:
-
a detector responsive to a signal generated from a detectable substance equilibrated within a subject'"'"'s extracellular fluid; at least one barrier enclosing the detector and at least a portion of a body part of the subject, the barrier defining a volume of extracellular fluid within which the signal is detected, said at least one barrier adapted to prevent a signal external to the volume portion from reaching the detector; and signal processing means for determining a clearance rate of the detectable substance by measuring depletion of a quantity of said detectable substance within the defined volume of extracellular fluid wherein said detector is responsive to multiple signals and further comprising a discriminator for resolving multiple signals, such that the signals generated by the detectable substance may be distinguished from a signal generated by another substance, wherein said signal by said another detectable substance indicates a change in the defined volume of extracellular fluid.
-
-
36. A method for measuring depletion of a detectable substance from a subject comprising:
-
providing a detectable substance to a subject, said detectable substance capable of equilibrating in a subject'"'"'s extracellular fluid; allowing said detectable substance to equilibrate in the subject'"'"'s extracellular fluid; wrapping a barrier around an upper arm portion of the subject, said upper arm portion defining a constant volume of the equilibrated extracellular fluid, positioning a detector housed within the barrier on the upper arm portion of the subject; allowing the detector to respond to a signal generated from the equilibrated substance within the defined constant volume; measuring a response of said detector to the equilibrated substance, the response indicative of the quantity of said detectable substance within the defined constant volume of said equilibrated extracellular fluid; and determining the depletion of said detectable substance from the measurement of a change in the quantity of said substance within the defined constant volume of said equilibrated extracellular fluid without withdrawing a fluid sample from the subject. - View Dependent Claims (37, 38)
-
Specification