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Human serum albumin expression construct

  • US 5,648,243 A
  • Filed: 09/21/1994
  • Issued: 07/15/1997
  • Est. Priority Date: 07/31/1991
  • Status: Expired due to Fees
First Claim
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1. A DNA construct adapted for the expression of human serum albumin in mammalian cells that do not normally express human serum albumin, comprising a promoter from a mammalian gene and a sequence coding for human serum albumin,(a) wherein the human serum albumin sequence comprises at least one, but not all, of the introns in the naturally occurring gene encoding the HSA protein;

  • (b) wherein said introns are selected to provide for expression of HSA in said mammalian cells at levels equal to or greater than levels resulting from the expression of the naturally occurring HSA gene in said mammalian cells; and

    (c) wherein said naturally occurring HSA gene encodes the HSA protein and includes exons and introns in their native positional relationships.

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